癌症仍然是全球健康挑战，需要探索新型治疗药物。目前的治疗方案无法压倒和治愈癌症负担。因此，识别具有有效抗癌活性的新生物活性分子实体是当前的需要。鞣花单宁香叶素 (GN) 是一种基于证据的新型生物活性分子实体 (BME)，可从不同的天然来源获得，可有效对抗癌症。这篇叙述性综述试图调查 2005 年至 2023 年 BME-GN 作为针对多种癌症的有效分子抗癌疗法的潜力。我们提供有关 GN 的药理学优势、代谢物概况以及调节与癌症标志相关的多个分子靶点的能力的信息。使用搜索词“香叶素”、“没食子酸”、“鞣花单宁”、“药理学特性”、“健康”、“抗氧化剂”、“细胞凋亡”、“疾病管理”、“抗增殖”、“体外”， “抗炎”、“抗血管生成”、“体内”和“临床试验”，我们使用 Scopus、Web of Science、Google Scholar 和 PubMed 检索了科学文献。我们删除了包含重叠或同等内容的出版物，并使用每期的最新评论作为我们的主要参考。从最初的 430 篇文章中，有 52 项研究符合搜索标准。这些研究共同提供了大量的体外、体内和临床证据，证明 GN 具有对抗多种癌症的潜力。机制见解揭示了它参与促进细胞凋亡、抗炎和调节与癌症特征有关的关键信号通路。 GN 的多效药理学和分子治疗特性强烈表明其作为一种有前途的抗癌药物的潜力。版权所有 © 2023。由 Elsevier B.V. 出版。

Cancer remains a global health challenge, necessitating the exploration of novel therapeutic agents. Current treatment options are unable to overwhelm and cure the cancer burden. Hence, identifying new bioactive molecular entities with potent anticancer activity is the need of the hour. Ellagitannin Geraniin (GN) is one such evidence-based novel bioactive molecular entity (BME) available from different natural sources that can effectively combat cancer. This narrative review attempts to investigate the potential of BME-GN from 2005 to 2023 as an efficient molecular anti-cancer therapeutic against diverse cancers. We provide information on GN's pharmacological advantages, metabolite profile, and capacity to modulate multiple molecular targets involved in the hallmarks of cancer. Using the search terms "Geraniin," "Gallic acid," "Ellagitannin," "pharmacological properties," "health," "antioxidant," "apoptosis," "disease management," "anti-proliferative," "in vitro," "anti-inflammatory," "anti-angiogenic," "in vivo," and "clinical trials," We searched the scientific literature using Scopus, Web of Science, Google Scholar, and PubMed. We removed publications that included overlap or equivalent content and used the most recent review on each issue as our primary reference. From an initial pool of 430 articles, 52 studies met the search criteria. These studies collectively provide substantial in vitro, in vivo, and clinical evidence of GN's potential to combat diverse cancers. Mechanistic insights revealed its involvement in fostering apoptosis, anti-inflammatory, and modulation of key signalling pathways implicated in the hallmarks of cancer. GN's pleiotropic pharmacological and molecular therapeutic properties strongly suggest its potential as a promising anticancer agent.Copyright © 2023. Published by Elsevier B.V.