神经系统疾病，包括脑损伤、脑肿瘤和神经退行性疾病，是全球第二大死亡原因。探索有效的神经系统疾病新疗法长期以来一直是临床实践中的研究热点问题。近年来，微针（MN）因其被认为是一种“无痛、非侵入性”的新型透皮给药方法而备受关注，其特点是生物相容性和可持续性。 MN 的优势为针对神经系统疾病的潜在治疗干预开辟了道路。这篇综述简要概述了 MN 领域的进展，重点介绍了其在神经系统疾病治疗中的应用。值得注意的是，还讨论了 MN 的发展趋势和未来的挑战。版权所有 © 2024 Elsevier B.V. 保留所有权利。

Neurological disorders, including brain injury, brain tumors, and neurodegenerative diseases, rank as the second leading cause of death worldwide. Exploring effective new treatments for neurological disorders has long been a hot research issue in clinical practice. Recently, microneedles (MNs) have attracted much attention due to their designation as a "painless and non-invasive" novel transdermal delivery method, characterized by their biocompatibility and sustainability. The advantages of MNs open an avenue for potential therapeutic interventions targeting neurological disorders. This review presents a concise overview of progress in the field of MNs, with highlights on the application in the treatment of neurological disorders. Notably, trends in the development of MNs and future challenges are also discussed.Copyright © 2024 Elsevier B.V. All rights reserved.