与诊断出患有乳腺癌的老年女性相比，年轻女性更有可能死于乳腺癌，并且更有可能在短期和长期内遭受心理社会痛苦。年轻女性乳腺癌研究 (YWS) 是一项多中心前瞻性队列研究，旨在解决我们对这一弱势群体和研究不足的人群的认识空白。YWS 招募了 1302 名新诊断为 0-IV 期乳腺癌、年龄为 40 岁或以下的女性，年龄为 40 岁或以下。 2006 年至 2016 年间北美 13 个学术和社区站点。纵向患者报告的结果数据通过多个时间点的临床数据提取和生物样本收集进行补充。与生育力相关的主要发现包括近 40% 的参与者在诊断后对怀孕感兴趣;在那些表示有兴趣的人中，10% 的人追求保留生育能力。总体而言，大约 10% 的 YWS 参与者在诊断后的前 5 年内怀孕； 5年后怀孕的随访仍在进行中。专注于心理社会结果的研究以生活质量、创伤后压力和对复发的恐惧为特征，研究结果详细说明了与许多年轻女性在积极治疗期间和之后面临的巨大心理社会负担相关的因素。多项研究利用了 YWS 生物样本，包括肿瘤分析的全外显子组测序，显示年轻（年龄≤35 岁）与老年 Luminal A 乳腺癌女性以不同的频率发生选择性体细胞改变，以及一项探索不确定性克隆造血的研究潜力发现这在年轻幸存者中很少见。中位随访时间约为 10 年，该队列在许多相关的长期结果方面刚刚成熟，并为进一步研究和建立合作以解决我们的知识差距提供了绝佳的机会，最终目标是改善患有乳腺癌的年轻女性的护理和结果。NCT01468246.© 作者（或其雇主）2024。根据 CC BY-NC 允许重复使用。禁止商业再利用。请参阅权利和权限。由英国医学杂志出版。

Compared with older women diagnosed with breast cancer, younger women are more likely to die of breast cancer and more likely to suffer psychosocially in both the short-term and long term. The Young Women's Breast Cancer Study (YWS) is a multisite prospective cohort study established to address gaps in our knowledge about this vulnerable and understudied population.The YWS enrolled 1302 women newly diagnosed with stages 0-IV breast cancer at age 40 years or younger at 13 academic and community sites in North America between 2006 and 2016. Longitudinal patient-reported outcome data are complemented by clinical data abstraction and biospecimen collection at multiple timepoints.Key findings related to fertility include that nearly 40% of participants were interested in pregnancy following diagnosis; of those who reported interest, 10% pursued fertility preservation. Overall, approximately 10% of YWS participants became pregnant in the first 5 years after diagnosis; follow-up is ongoing for pregnancies after 5 years. Studies focused on psychosocial outcomes have characterised quality of life, post-traumatic stress and fear of recurrence, with findings detailing the factors associated with the substantial psychosocial burden many young women face during and following active treatment. Multiple studies have leveraged YWS biospecimens, including whole-exome sequencing of tumour analyses that revealed that select somatic alterations occur at different frequencies in young (age≤35) versus older women with luminal A breast cancer, and a study that explored clonal hematopoiesis of indeterminate potential found it to be rare in young survivors.With a median follow-up of approximately 10 years, the cohort is just maturing for many relevant long-term outcomes and provides outstanding opportunities to further study and build collaborations to address gaps in our knowledge, with the ultimate objective to improve care and outcomes for young women with breast cancer.NCT01468246.© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.