关于咖啡摄入量与肺癌风险之间关系的研究一直存在矛盾。本研究的目的是系统地回顾关于咖啡消费与肺癌风险之间关联的现有证据，并通过进行荟萃分析来量化这种关联。截至 2023 年 7 月，我们对在线数据库进行了全面的系统搜索，调查咖啡摄入量与肺癌风险之间的关联。报告此背景下的比值比 (OR)、比率或风险比 (RR) 或风险比 (HR) 和 95% 置信区间 (CI) 的所有前瞻性队列研究均包含在内。使用随机效应模型计算总体效应大小，并使用 Cochrane 的 Q 检验和 I2 检查研究间的统计异质性。本次系统评价和荟萃分析共纳入了 14 项前瞻性队列研究。我们发现咖啡摄入量与肺癌风险之间存在显着正相关（RR：1.28；95% CI：1.12，1.47）。当我们纳入合并分析论文并排除 5 项队列研究时，这种关联仍然显着（RR：1.37；95% CI：1.12，1.66）。使用 Egger 检验，我们没有观察到显着发表偏倚的证据 (P = 0.58)。此外，剂量反应分析显示，每天咖啡摄入量每增加 1 杯，肺癌风险就会增加 6%（RR：1.06；95% CI：1.03、1.09）。总之，我们发现咖啡摄入量与肺癌风险之间存在显着的正相关关系。© 2024。作者。

Studies on the association between coffee consumption and risk of lung cancer have been conflicting. The aim of this study was to systematically review the current evidence on the association between coffee consumption and risk of lung cancer and to quantify this association by performing a meta-analysis. A comprehensive systematic search was performed on online databases up to July 2023 investigating the association between coffee consumption and risk of lung cancer. All prospective cohort studies reporting odds ratios (ORs), rate or risk ratios (RRs), or hazard ratios (HRs) and 95% confidence intervals (CIs) in this context were included. The overall effect size was calculated using the random-effects model and statistical between-studies heterogeneity was examined using Cochrane's Q test and I2. A total of 14 prospective cohort studies were included in this systematic review and meta-analysis. We found a significant positive association between coffee consumption and risk of lung cancer (RR: 1.28; 95% CI: 1.12, 1.47). This association remained significant when we included a pooled analysis paper and excluded 5 cohort studies (RR: 1.37; 95% CI: 1.12, 1.66). We observed no proof of significant publication bias using Egger's test (P = 0.58). Moreover, dose-response analysis showed that each one cup/day increase in coffee consumption was related with a 6% higher lung cancer risk (RR: 1.06; 95% CI: 1.03, 1.09). In conclusion, we found a significant positive association between coffee consumption and risk of lung cancer.© 2024. The Author(s).