尽管肾细胞癌（RCC）是一种常见的癌症类型，但最常见的病理亚型透明细胞肾细胞癌（ccRCC）的进展分子机制仍然知之甚少。此外，干扰素刺激基因15（ISG15）与多种类型的癌症相关。本研究旨在探讨ISG15在ccRCC进展中的作用。ISG15在ccRCC中表达上调并与不良预后相关。 RNA序列分析和后续实验表明ISG15调节IL6/JAK2/STAT3信号传导以促进ccRCC增殖、迁移和侵袭。此外，我们的动物实验证实，持续的ISG15敲低可降低裸鼠肿瘤生长速度并促进细胞凋亡。 ISG15 调节 IL6/JAK2/STAT3 通路，使其成为 ccRCC 的潜在治疗靶点和预后生物标志物。© 2024。作者。

Although renal cell carcinoma (RCC) is a prevalent type of cancer, the most common pathological subtype, clear cell renal cell carcinoma (ccRCC), still has poorly understood molecular mechanisms of progression. Moreover, interferon-stimulated gene 15 (ISG15) is associated with various types of cancer; however, its biological role in ccRCC remains unclear.This study aimed to explore the role of ISG15 in ccRCC progression.ISG15 expression was upregulated in ccRCC and associated with poor prognosis. RNA sequence analysis and subsequent experiments indicated that ISG15 modulated IL6/JAK2/STAT3 signaling to promote ccRCC proliferation, migration, and invasion. Additionally, our animal experiments confirmed that sustained ISG15 knockdown reduced tumor growth rate in nude mice and promoted cell apoptosis. ISG15 modulates the IL6/JAK2/STAT3 pathway, making it a potential therapeutic target and prognostic biomarker for ccRCC.© 2024. The Author(s).