与模拟 PET/CT 相比，数字正电子发射断层扫描/计算机断层扫描 (PET/CT) 显示出更高的灵敏度和空间分辨率。本研究比较了数字和模拟 PET/CT 与 [68Ga]Ga-PSMA-11 对前列腺切除术后经历生化复发 (BCR) 的前列腺癌患者的诊断性能。前瞻性招募了 40 名经历过 BCR（定义为前列腺切除术后血清前列腺特异性抗原 (PSA) 浓度超过 0.2 ng/mL）的前列腺癌患者。这些患者根据血清 PSA 水平分为三组。将[68Ga]Ga-PSMA-11注射到每位患者体内，并使用模拟和数字PET/CT扫描仪采集图像。模拟和数字 PET/CT 显示出相当的病变检出率（71.8% vs. 74.4%）、灵敏度（85.0% vs. 90.0%）和阳性预测值（PPV，100.0% vs. 100.0%）。然而，无论血清 PSA 水平如何，数字 PET/CT 均比模拟 PET/CT 检测到更多病变（139 比 111），并且具有更高的最大标准化摄取值（SUVmax，14.3 比 10.3）和更高的 kappa 指数（0.657 比 0.502）。水平。在模拟和数字 PET/CT 上，病变检出率和受试者间一致性随着血清 PSA 水平的增加而增加。与模拟 PET/CT 相比，数字 PET/CT 在前列腺切除术后经历 BCR 的前列腺癌患者中检测到更多病灶，具有更高的 SUVmax 和更好的受试者间一致性。© 2024。作者。

Digital positron emission tomography/computed tomography (PET/CT) has shown enhanced sensitivity and spatial resolution compared with analog PET/CT. The present study compared the diagnostic performance of digital and analog PET/CT with [68Ga]Ga-PSMA-11 in prostate cancer patients who experienced biochemical recurrence (BCR) after prostatectomy. Forty prostate cancer patients who experienced BCR, defined as serum prostate-specific antigen (PSA) concentrations exceeding 0.2 ng/mL after prostatectomy, were prospectively recruited. These patients were stratified into three groups based on their serum PSA levels. [68Ga]Ga-PSMA-11 was injected into each patient, and images were acquired using both analog and digital PET/CT scanners. Analog and digital PET/CT showed comparable lesion detection rate (71.8% vs. 74.4%), sensitivity (85.0% vs. 90.0%), and positive predictive value (PPV, 100.0% vs. 100.0%). However, digital PET/CT detected more lesions (139 vs. 111) and had higher maximum standardized uptake values (SUVmax, 14.3 vs. 10.3) and higher kappa index (0.657 vs. 0.502) than analog PET/CT, regardless of serum PSA levels. On both analog and digital PET/CT, lesion detection rates and interrater agreement increased with increasing serum PSA levels. Compared with analog PET/CT, digital PET/CT detected more lesions with a higher SUVmax and better interrater agreement in prostate cancer patients who experienced BCR after prostatectomy.© 2024. The Author(s).