诊断后体重增加在早期乳腺癌中很常见，并且与复发和死亡风险增加相关。有意识的减肥很难维持，而数字生活方式干预可能提供一种可扩展的方法来应对这一挑战。在这项前瞻性单臂研究（ClinicalTrials.gov NCT04753268；2021 年 2 月 15 日）中，关键资格标准包括：I-III 期乳腺癌、体重指数 (BMI) ≥27.5kg/m2 以及完成癌症治疗≥6入学前几个月。为参与者提供了行为改变移动应用程序（Noom®）。主要终点是自我报告的体重从基线到 26 周的变化。次要终点包括参与度、身体活动的变化、饮食模式和患者报告的结果 (PRO)。总共有 31 名患者入组（平均年龄 56.8±9.9，平均基线 BMI 33.5kg/m2±6.5）。平均体重变化为-4.8kg（±4.4，P<±0.001），平均体重变化百分比为-5.6%（±5.0%）； 11/31 名患者 (35.5%) 的体重减轻了 ≥ 5%。与减肥 ≥5% 相关的数字应用程序参与度指标包括阅读的文章 (P = 0.012)、记录的体重 (P = 0.006)、记录的食物记录 (P = 0.001)、发送的消息 (P = 0.001) 和应用程序打开计数（P = 0.014）。平均每日步数 (P = 0.004)、GPAQ 分数 (P = 0.002) 和身体形象量表分数 (P < 0.001) 均显着增加。平均能量摄入始终保持在 1300-1400 kcal/天的卡路里限制范围内。在这项研究中，乳腺癌幸存者高度参与行为改变智能手机应用程序，该应用程序导致临床上显着的体重减轻、增加体力活动、维持能量限制饮食以及改善身体形象。© 2024。作者。

Post-diagnosis weight gain is common in early-stage breast cancer and is associated with increased risk of recurrence and mortality. Intentional weight loss is difficult to maintain, and digital lifestyle interventions may provide a scalable approach to address this challenge. In this prospective single-arm study (ClinicalTrials.gov NCT04753268; February 15, 2021), key eligibility criteria included: stage I-III breast cancer, body mass index (BMI) ≥ 27.5 kg/m2, and completion of cancer treatment ≥6 months before study enrollment. Participants were provided with a behavioral change mobile application (Noom®). The primary endpoint was a change in self-reported weight from baseline to 26 weeks. Secondary endpoints included engagement, changes in physical activity, dietary patterns, and patient-reported outcomes (PRO). In total, 31 patients were enrolled (mean age 56.8 ± 9.9, mean baseline BMI 33.5 kg/m2 ± 6.5). The mean weight change was -4.8 kg ( ± 4.4, P < 0.001), mean percent weight change was -5.6% ( ± 5.0%); 11/31 patients (35.5%) lost ≥5% of their initial weight. Metrics of digital application engagement associated with weight loss ≥5% included articles read (P = 0.012), weights logged (P = 0.006), food records logged (P = 0.001), messages sent (P = 0.001), and application open count (P = 0.014). Significant increases were seen in mean daily step count (P = 0.004), GPAQ scores (P = 0.002), and Body Image Scale scores (P < 0.001). Mean energy intake remained consistently in a calorie-restricted range of 1300-1400 kcal/day. In this study, breast cancer survivors were highly engaged with a behavioral change smartphone application which led to clinically significant weight loss, increased physical activity, maintenance of an energy-restricted diet, and improvements in body image.© 2024. The Author(s).