尽管过敏与癌症之间的关系已得到广泛研究，但过敏在头颈癌 (HNC) 中的作用似乎不太一致。目前尚不清楚，在存在大量环境风险因素（包括饮酒、槟榔和吸烟）的情况下，过敏是否可以独立影响 HNC 风险。本研究旨在寻找这种关联。我们在一项以医院为基础的病例对照研究中研究了过敏与 HNC 风险之间的关系，该研究有 300 名病例和 375 名匹配对照。使用逻辑回归模型来估计比值比 (OR) 和 95% 置信区间，并控制年龄、性别、吸烟和鸦片使用史、饮酒量和社会经济状况。我们的研究表明，在调整混杂因素后，与过敏症状相关的 HNC 风险显着降低。患有任何类型过敏的人患 HNC 的风险大大降低（OR 0.42，95% CI 0.28，0.65）。不同类型过敏的 OR 显着降低了 58-88%。过敏女性的 HNC 减少风险高于过敏男性（71% vs. 49%）。过敏在 HNC 发展风险中发挥着重要作用。未来有必要研究免疫生物标志物，包括细胞因子谱和遗传多态性，以进一步阐明过敏与 HNC 之间的关系。了解过敏和 HNC 之间的关系可能有助于制定有效的策略来减少和治疗 HNC。© 2024。作者。

Although the relationship between allergies and cancer has been investigated extensively, the role of allergies in head and neck cancer (HNC) appears less consistent. It is unclear whether allergies can independently influence the risk of HNC in the presence of substantial environmental risk factors, including consumption of alcohol, betel quid, and cigarettes. This study aims to find this association. We examined the relationship between allergies and HNC risk in a hospital-based case-control study with 300 cases and 375 matched controls. Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals, controlling for age, sex, tobacco smoking and opium usage history, alcohol consumption, and socioeconomic status. Our study showed a significant reduction in the risk of HNC associated with allergy symptoms after adjusting for confounders. The risk of HNC was greatly reduced among those with any type of allergy (OR 0.42, 95% CI 0.28, 0.65). The ORs were considerably reduced by 58-88% for different kinds of allergies. The risk of HNC reduction was higher in allergic women than in allergic men (71% vs. 49%). Allergies play an influential role in the risk of HNC development. Future studies investigating immune biomarkers, including cytokine profiles and genetic polymorphisms, are necessary to further delineate the relationship between allergies and HNC. Understanding the relationship between allergies and HNC may help to devise effective strategies to reduce and treat HNC.© 2024. The Author(s).