专业姑息治疗 (SPC) 的主要目的是改善因危及生命的疾病而导致高症状负担的患者的生活质量 (QoL)。这项随机研究旨在评估早期整合 SPC 与肿瘤特异性姑息治疗对胃肠道 (GI) 癌症患者的生活质量影响。我们将晚期 GI 癌症的门诊患者随机分配至早期整合 SPC 与肿瘤特异性姑息治疗或单独进行肿瘤特异性治疗。主要终点是使用癌症治疗一般功能评估 (FACT-G) 问卷在基线和每六周评估生活质量。共有 118 名患者被随机分组​​。分配到早期 SPC 整合的患者与对照组之间的总 FACT-G 评分差异为 5.2 分（95% CI：-0.1 至 10.5，p = 0.216）、6.7 分（95% CI：0.2 至 13.3，p = 0.172） ），第 6、12 和 24 周分别为 13 分（95% CI：5.7 至 20.2，p = 0.004）。这项前瞻性随机试验强化了晚期晚期患者早期将 SPC 与肿瘤特异性治疗相结合的论点。胃肠道癌症。我们发现晚期胃肠道癌症患者的生活质量在随机分配到早期整合家庭 SPC.ClinicalTrials.gov 后 24 周有所改善（参考：NCT02246725）。© 2024。作者。

The primary aim of specialised palliative care (SPC) is to improve the quality of life (QoL) for patients with a high symptom burden from a life-threatening disease. This randomised study aimed to assess the QoL impact of early integration of SPC alongside tumour-specific palliative treatment in patients with gastrointestinal (GI) cancers.We randomly assigned ambulatory patients with advanced GI cancer to early integration of SPC and palliative tumour-specific treatment or tumour-specific treatment alone. The primary endpoint was QoL assessed at baseline and every sixth week using the Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire.A total of 118 patients were randomised. The difference in total FACT-G score between patients assigned to early integration with SPC and controls was 5.2 points (95% CI: -0.1 to 10.5, p = 0.216), 6.7 points (95% CI: 0.2 to 13.3, p = 0.172), and 13 points (95% CI: 5.7 to 20.2, p = 0.004) at weeks 6, 12, and 24, respectively.This prospective randomised trial strengthens the argument for early integration of SPC with tumour-specific treatment in patients with advanced GI cancers. We found an improved QoL for patients with advanced GI cancer 24 weeks after randomisation to early integration of home-based SPC.ClinicalTrials.gov (ref: NCT02246725).© 2024. The Author(s).