表观遗传机制已被证明在胃肠道 [GI] 癌症的发生和进展中发挥着关键作用。这些机制涉及 DNA 和组蛋白的修饰，这些修饰可以改变基因表达模式，并可能导致癌症的发生和进展。近年来，表观遗传疗法已成为治疗胃肠道癌症的一种有前景的方法。这些疗法针对特定的表观遗传修饰，例如 DNA 甲基化和组蛋白乙酰化，以恢复正常的基因表达模式并抑制癌细胞生长。几种表观遗传药物已被批准用于治疗胃肠道癌症。此外，正在研究将表观遗传疗法与其他治疗方法（例如化疗药物）结合使用，以改善治疗结果。我们概述了表观遗传机制在胃肠道癌症治疗中的作用，旨在重点关注表观遗传药物在临床和临床前胃肠道癌症研究中使用的最新证据，包括胃癌、食道癌、肝癌、胰腺癌和结直肠癌。总体而言，表观遗传机制在胃肠道癌症治疗中的作用是一个活跃的研究领域，有可能改善患者的治疗结果并推进癌症治疗策略。版权所有© Bentham Science Publishers；如有任何疑问，请发送电子邮件至 epub@benthamscience.net。

Epigenetic mechanisms have been shown to play a critical role in the development and progression of gastrointestinal [GI] cancers. These mechanisms involve modifications to DNA and histones that can alter gene expression patterns and may contribute to the initiation and progression of cancers. In recent years, epigenetic therapies have emerged as a promising approach to treating GI cancers. These therapies target specific epigenetic modifications, such as DNA methylation and histone acetylation, to restore normal gene expression patterns and inhibit cancer cell growth. Several epigenetic drugs have been approved for the treatment of GI cancers. Moreover, the use of epigenetic therapies in combination with other treatments, such as chemotherapeutic agents, is being studied to improve treatment outcomes. We have provided an overview of the role of epigenetic mechanisms in GI cancer treatment aimed to focus on recent evidence of the use of epigenetic agents in clinical and preclinical GI cancer studies, including gastric, esophageal, hepatic, pancreatic, and colorectal cancers. Overall, the role of epigenetic mechanisms in GI cancer treatments is an active area of research with the potential to improve patients' treatment outcomes and advance cancer treatment strategies.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.