不要忘记粒细胞区室在 T 细胞介导的抗肿瘤免疫中的作用。
Do Not Forget the Granulocytic Compartment's Role in T cell-Mediated Antitumor Immunity.
发表日期：2024 Jul 02
作者：
Udo S Gaipl
来源：
Cancer Immunology Research
摘要：
抗肿瘤免疫反应主要由 CD8 细胞毒性 T 细胞 (CTL) 介导。但肿瘤微环境中的免疫调节因素决定了这些反应的有效性。在本期中，Wei 及其同事报告了 CTL 衍生的 IL3 在刺激嗜碱性粒细胞产生 IL4 方面的新作用，IL4 反过来又激活、重新编程和稳定 CTL。这些发现强调了先天性免疫系统和适应性免疫系统之间的串扰对于引发有效的抗肿瘤免疫的重要性。参见 Wei 等人的相关文章，第 17 页。 822 (3).©2024 美国癌症研究协会。
Antitumor immune responses are predominantly mediated by CD8+ cytotoxic T cells (CTLs). But immune-modulatory factors in the tumor microenvironment determine the effectiveness of these responses. In this issue, Wei and colleagues report a new role for CTL-derived IL3 in stimulating basophilic granulocytes to produce IL4, which, in turn, activates, reprograms, and stabilizes CTLs. These findings stress the importance of the crosstalk between the innate and adaptive immune systems to elicit efficient antitumor immunity. See related article by Wei et al., p. 822 (3).©2024 American Association for Cancer Research.