用于细胞图案化的滚动螺旋微型机器人。
Rolling Helical Microrobots for Cell Patterning.
发表日期:2023 Oct
作者:
Yanda Yang, Fatma Ceren Kirmizitas, Max Sokolich, Alejandra Valencia, David Rivas, M Çağatay Karakan, Alice E White, Andreas A Malikopoulos, Sambeeta Das
来源:
BIOMEDICINE & PHARMACOTHERAPY
摘要:
微型机器人是一种能够执行微型任务的不受束缚的微型设备,在机器人和生物医学领域获得了极大的关注。这些设备在各种工业和科学应用中具有巨大的潜力,包括靶向药物输送和细胞操作。在这项研究中,我们提出了一种专门为生物相容性细胞图案化而设计的新型磁力滚动螺旋微型机器人。我们的微型机器人结合了开环和闭环控制机制,为各种应用提供灵活、精确、快速的控制。通过实验,我们展示了微型机器人通过推动细胞、滚动细胞并将细胞排列成所需图案来操纵细胞的能力。这一结果特别重要,因为它对组织工程和类器官发育等多种生物应用具有影响。此外,我们还展示了微型机器人在闭环控制系统中的有效性,它成功地遵循从起点到目的地的预定路径。细胞操纵能力和轨迹跟踪性能的结合凸显了我们的磁力滚动螺旋微型机器人的多功能性和潜力。高精度控制和导航微型机器人的能力为先进的生物医学应用开辟了新的可能性。这些发现有助于不断增长微生物学知识体系,并为该领域的进一步研究和开发铺平道路。
Microrobots, untethered miniature devices capable of performing tasks at the microscale, have gained significant attention in the fields of robotics and biomedicine. These devices hold immense potential for various industrial and scientific applications, including targeted drug delivery and cell manipulation. In this study, we present a novel magnetic rolling helical microrobot specifically designed for bio-compatible cell patterning. Our microrobot incorporates both open-loop and closed-loop control mechanisms, providing flexible, precise, and rapid control for various applications. Through experiments, we demonstrate the microrobot's ability to manipulate cells by pushing them while rolling and arranging cells into desired patterns. This result is particularly significant as it has implications for diverse biological applications such as tissue engineering and organoid development. Moreover, we showcase the effectiveness of our microrobot in a closed-loop control system, where it successfully follows a predetermined path from an origin to a destination. The combination of cellular manipulation capabilities and trajectory-tracking performance underlines the versatility and potential of our magnetic rolling helical microrobot. The ability to control and navigate the microrobot with high precision opens up new possibilities for advanced biomedical applications. These findings contribute to the growing body of knowledge in microbotics and pave the way for further research and development in the field.