目的是利用两样本孟德尔随机化探讨白细胞介素 6 (IL6) 和 C 反应蛋白 (CRP) 对恶性黑色素瘤 (MM) 的影响。本研究的数据来自 IEU Open GWAS 项目网站的基因组-关于白细胞介素 6、C 反应蛋白水平和恶性黑色素瘤的广泛关联研究数据 (GWAS)。以逆方差加权（IVW）法为主，辅以MR-Egger回归和加权中位数法。最后进行水平多变量效度和异质性检验，评估结果的稳定性和可靠性。单变量双样本MR分析结果显示CRP对MM无显着影响：逆方差加权法（OR=0.999，95% CI ：0.998-1.001，P=0.343），MR-Egger回归（OR=1.000，95％CI：0.998-1.001，P=0.180），加权中位数法（OR=0.999，95％CI：0.997至1.000，P = 0.583）和加权模型（OR = 0.999，95% CI：0.998 至 1.001，P = 0.328）。另外，IL-6对MM没有显着影响：逆方差加权法（OR=1.001，95%CI：0.999至1.002，P=0.461），MR-Egger回归（OR=1.000，95%CI：0.997至1.004） ，P=0.910）、加权中位数法（OR=1.000，95%CI：0.998至1.002，P=0.749）和加权模式（OR=1.000，95%CI：0.998至1.002，P=0.820）。 C 反应蛋白和 IL-6 与恶性黑色素瘤风险之间没有因果关系。版权所有 © 2024 Wang、Zheng 和 Pan。

The goal was to explore the effect of interleukin-6 (IL6) and C reactive protein (CRP) on malignant melanoma (MM) using two-sample Mendelian randomization.Data for this study were obtained from the IEU Open GWAS project website for genome-wide association study data (GWAS) on interleukin-6, C reactive protein levels and malignant melanoma. Inverse variance weighted (IVW) method was mainly used and supplemented with MR-Egger regression and weighted median. Finally, horizontal multivariate validity and heterogeneity tests were performed to assess the stability and reliability of the results.The results of univariate two-sample MR analyses showed no significant effect of CRP on MM: inverse variance weighting method (OR=0.999, 95% CI: 0.998-1.001, P=0.343), MR-Egger regression (OR= 1.000, 95% CI: 0.998-1.001, P= 0.180), and weighted median method (OR= 0.999, 95% CI: 0.997 to 1.000, P= 0.583), and weighted model (OR= 0.999, 95% CI: 0.998 to 1.001, P= 0.328). Also,IL-6 had no significant effect on MM: inverse variance weighting method (OR= 1.001, 95% CI: 0.999 to 1.002, P=0.461), MR-Egger regression (OR= 1.000, 95% CI: 0.997 to 1.004, P= 0.910), weighted median method (OR= 1.000, 95% CI: 0.998 to 1.002, P= 0.749), and weighted mode (OR= 1.000, 95% CI: 0.998 to 1.002, P= 0.820).There was no causal relationship between C-reactive protein and IL-6 on the risk of malignant melanoma.Copyright © 2024 Wang, Zheng and Pan.