如何巧妙地设计多效光敏剂（PS），包括多模态成像和多通道治疗，对于恶性肿瘤的高度时空可控精准光疗具有重要意义。在此，一种新型多功能基于锌（II）酞菁的平面小分子两亲物成功设计并合成了(ZnPc 1)，其中引入具有光致电子转移效应的N原子，增强了近红外吸收率和非辐射发热。在简单自组装成纳米颗粒（NP）后，ZnPc 1 NP将表现出增强的多模态成像特性，包括荧光（FL）成像（FLI）/光声（PA）成像（PAI）/红外（IR）热成像，并被进一步使用指导联合光动力治疗（PDT）和光热治疗（PTT）。在多模态成像的自我引导下，ZnPc 1 NPs可以从垂直和水平边界精确定位肿瘤，实现高效、准确的治疗因此，将FL/PA/IR多模态成像和PDT/PTT协同治疗途径整合到一个ZnPc 1中可以为下一代光疗提供蓝图，为肿瘤诊断和治疗一体化提供新的范例以及精准癌症治疗的广阔前景。© 2024 Sun et al.

How to ingeniously design multi-effect photosensitizers (PSs), including multimodal imaging and multi-channel therapy, is of great significance for highly spatiotemporal controllable precise phototherapy of malignant tumors.Herein, a novel multifunctional zinc(II) phthalocyanine-based planar micromolecule amphiphile (ZnPc 1) was successfully designed and synthesized, in which N atom with photoinduced electron transfer effect was introduced to enhance the near-infrared absorbance and nonradiative heat generation. After simple self-assembling into nanoparticles (NPs), ZnPc 1 NPs would exhibit enhanced multimodal imaging properties including fluorescence (FL) imaging (FLI) /photoacoustic (PA) imaging (PAI) /infrared (IR) thermal imaging, which was further used to guide the combined photodynamic therapy (PDT) and photothermal therapy (PTT).It was that under the self-guidance of the multimodal imaging, ZnPc 1 NPs could precisely pinpoint the tumor from the vertical and horizontal boundaries achieving highly efficient and accurate treatment of cancer.Accordingly, the integration of FL/PA/IR multimodal imaging and PDT/PTT synergistic therapy pathway into one ZnPc 1 could provide a blueprint for the next generation of phototherapy, which offered a new paradigm for the integration of diagnosis and treatment in tumor and a promising prospect for precise cancer therapy.© 2024 Sun et al.