研究动态
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真核细胞能量转导的生物能量神话。

Bioenergetic myths of energy transduction in eukaryotic cells.

发表日期:2024
作者: Guy C Brown
来源: Frontiers in Molecular Biosciences

摘要:

真核细胞能量转导的研究分为生物能量学和生理学,反映并促成了此处考虑的各种生物能量学神话:1)ATP 产生 = 能量产生,2)能量转导仅限于线粒体(加上糖酵解和叶绿体) ,3)线粒体仅在需要时产生热量,4)与线粒体相比,糖酵解效率较低,5)线粒体是细胞中活性氧(ROS)的主要来源。这些神话构成了错误或不平衡的细胞“有丝分裂中心”观点。实际上,线粒体是细胞中能量耗散和产热的主要场所,这是哺乳动物线粒体的重要功能。能量转导和 ROS 产生发生在整个细胞中,特别是细胞质和质膜,所有细胞膜都充当二维能量导管。糖酵解效率很高,并且每个 ATP 产生的热量比线粒体少,这可能解释了它在肌肉和癌细胞中的使用增加。版权所有 © 2024 Brown。
The study of energy transduction in eukaryotic cells has been divided between Bioenergetics and Physiology, reflecting and contributing to a variety of Bioenergetic myths considered here: 1) ATP production = energy production, 2) energy transduction is confined to mitochondria (plus glycolysis and chloroplasts), 3) mitochondria only produce heat when required, 4) glycolysis is inefficient compared to mitochondria, and 5) mitochondria are the main source of reactive oxygen species (ROS) in cells. These myths constitute a 'mitocentric' view of the cell that is wrong or unbalanced. In reality, mitochondria are the main site of energy dissipation and heat production in cells, and this is an essential function of mitochondria in mammals. Energy transduction and ROS production occur throughout the cell, particularly the cytosol and plasma membrane, and all cell membranes act as two-dimensional energy conduits. Glycolysis is efficient, and produces less heat per ATP than mitochondria, which might explain its increased use in muscle and cancer cells.Copyright © 2024 Brown.