泛热带酸浆传统上用于预防和治疗各种疾病、疾病和癌症。虽然对该物种的大多数早期研究都集中在叶和茎提取物的植物化学上，但最近的研究表明，其果实可能含有具有医学意义的生物活性化合物。在这项研究中，我们研究了 P. minima 果实提取物对结直肠癌细胞系的细胞毒性，并通过高分辨率串联质谱分析揭示了其植物化学特征。用水果提取物处理 24 小时后，在结直肠癌细胞系 HCT116 和 HT29 中观察到细胞质收缩和细胞核浓缩，表明诱导了程序性细胞死亡。从植物化学角度，鉴定出 71 种推定代谢物。据报道，其中一些代谢物可以不同程度地抑制癌症，进一步支持了假定的代谢物与本研究中证明的针对结直肠癌细胞的细胞毒性的相关性。

The pantropical Physalis minima are traditionally used for the prevention and treatment of various illnesses, diseases, and cancers. While most earlier studies on the species have focused on the phytochemistry of the leaf and stem extracts, recent studies have indicated that its fruit may contain bioactive compounds of medical interest. In this study, we investigated the cytotoxicity of extracts from the fruit of P. minima against colorectal cancer cell lines and revealed its phytochemical profile via high-resolution tandem mass spectrometry analysis. Following a 24-h treatment with the fruit extract, cytoplasm shrinkage and nucleus condensation were observed in the colorectal cancer cell lines HCT116 and HT29, indicating the induction of programmed cell death. Phytochemically, 71 putative metabolites were identified. Some of these metabolites have been reported to inhibit cancers to varying degrees, further supporting the correlation of the putative metabolites with the cytotoxicity against colorectal cancer cells demonstrated in this study.