胃溃疡（GU）发病率的增加对公众健康构成了重大威胁。本研究旨在评估三角钽叶水提取物 (AETT) 对乙醇引起的胃溃疡的胃保护特性。通过给大鼠口服单剂量 5 mLkg-1 90% 乙醇诱导 GU，并通过口服治疗研究 200 mgkg-1 bw 的 AETT 和 20 mgkg-1 bw 奥美拉唑的保护作用 14 天。评估了 AETT 对抗炎、氧化还原测定、溃疡指数 (UI) 和胃粘膜组织学改变的影响。与未治疗组相比，乙醇诱导的大鼠出现胃炎症，髓过氧化物酶（MPO）和肿瘤坏死因子-α 水平显着增加。胃溃疡组表现出氧化应激加剧，同时抗氧化酶活性下降。大鼠暴露于乙醇会导致脂质过氧化的诱导，显着升高胃内丙二醛（MDA）浓度。然而，AETT 或奥美拉唑治疗通过减弱与炎症相关的标志物的表达，在胃粘膜内表现出显着的抗炎作用。 AETT 证明 MDA 和 H2O2 浓度降低，从而减轻脂质过氧化级联的进展。此外，AETT 通过增强保护酶的功能和提高谷胱甘肽 (GSH) 浓度，表现出减轻乙醇引起的氧化损伤的作用。总体而言，AETT 增强了细胞保护性抗氧化酶的活性，减轻了氧化应激和炎症的影响，抑制了脂质过氧化，并降低了 UI 评分。这些有益效果可归因于 AETT 中存在的植物化学物质，包括 6,10,14-三甲基-2-十五酮和植醇。这项研究的结果确立了 AETT 的传统草药主张。

The increase in the incidence of gastric ulcer (GU) has posed major threat on public health. This research aimed to evaluate gastroprotective properties of the aqueous leaf extract of Talium triangulare (AETT) in ethanol-induced gastric ulceration. GU was induced via oral administration of single dose of 5 mLkg-1 of 90% ethanol in rats and protection of 200 mgkg-1 bw of AETT and 20 mgkg-1 bw of omeprazole was investigated for 14 d via oral treatment. Influence of AETT on anti-inflammatory, redox assays, ulcer index (UI), and gastric mucosa histological alterations were evaluated. Significant increase in myeloperoxidase (MPO) and tumor necrosis factor-alpha levels compared to untreated group established gastric inflammation in rats induced by ethanol. Gastric ulcerated group exhibited heightened oxidative stress with concurrent decline in activities of antioxidant enzymes. Ethanol exposure to rats resulted in induction of lipid peroxidation, prominently elevating gastric malondialdehyde (MDA) concentration. Nevertheless, treatment with AETT or omeprazole exhibited substantial anti-inflammatory effects within gastric mucosa by attenuating expression of markers associated with inflammation. AETT demonstrated reduction in concentrations of MDA and H2O2, thereby alleviating progression of lipid peroxidation cascades. Also, AETT exhibited mitigating effect on ethanol-induced oxidative harm by enhancing the functionality of protective enzymes and elevating glutathione (GSH) concentration. Overall, AETT exhibited enhancements in activities of cytoprotective antioxidant enzymes, mitigated impact of oxidative stress and inflammation, inhibited lipid peroxidation, and decreased UI score. These beneficial effects could be attributed to phytochemicals present in AETT including 6,10,14-trimethyl-2-pentadecanone and Phytol. Outcome of this study established the traditional herbal claims of AETT.