幽门螺杆菌（Helicobacter pylori，Hp）是一种引起胃肠道感染的常见革兰氏阴性杆菌，主要存在于胃上皮细胞表面和粘液中，与胃溃疡、胃癌、胃粘膜相关淋巴瘤有关。研究表明， Hp可诱发或加剧某些胃外疾病，与2019冠状病毒病的发生有关。推测Hp可能通过刺激炎性细胞因子的产生或诱发交叉免疫反应，间接或直接参与疾病的发生和发展。另外，Hp可进入念珠菌体内，不断释放毒素，起到逃避宿主免疫系统识别和药物杀菌作用的作用。本文对近年来Hp相关胃外疾病的研究进展进行综述，旨在探讨Hp相关胃外疾病的研究进展。引起临床工作者对Hp相关胃外疾病的重视，丰富Hp感染知识，制定对策，避免Hp加重或引发其他疾病。

Helicobacter pylori (Hp) is a common Gram-negative bacillus causing gastrointestinal infections.It mainly exists on the surface of gastric epithelial cells and in mucus and is associated with gastric ulcers,gastric cancer,and gastric mucosa-associated lymphomas.Studies have shown that Hp can induce or exacerbate certain extragastric diseases and is associated with the occurrence of coronavirus disease 2019.It is hypothesized that Hp may be indirectly or directly involved in the occurrence and development of diseases by stimulating the production of inflammatory cytokines or inducing cross-immune reactions.In addition,Hp can enter Candida to release toxins continuously and play a role in escaping the recognition of the host immune system and the bactericidal effect of drugs.This article reviews the research progress in Hp-associated extragastric diseases in recent years,aiming to draw the attention of clinical workers to Hp-associated extragastric diseases and enrich the knowledge about Hp infection for formulating countermeasures to avoid the aggravation or triggering of other diseases by Hp.