旨在研究乳腺癌女性（新）辅助化疗期间大负荷力量训练对肌肉力量、身体成分、肌纤维大小、卫星细胞和肌核的影响。患有 I-III 期乳腺癌的女性被随机分配到力量训练组 (ST，n = 23)，在化疗期间每周进行两次监督下的大负荷力量训练，或常规护理对照组 (CON，n = 17)。测量肌肉力量和身体成分并进行活组织检查。在第一个化疗周期之前（T0）和化疗和训练之后（T1）收集股外侧肌。在胸举 (ST: 10 ± 8%, p < .001, CON: -3 ± 5%, p = .023) 和腿举 (ST: 11 ± 8) 中, ST 组的肌肉力量显着高于 CON 组%，p < .001，CON：3 ± 6%，p = .137）。两组的去脂体重均减少（ST：-4.9±±4.0%，p< .001，CON：-5.2±±4.9%，p= .004），脂肪质量增加（ST：15.3±±16.5%，p< ）。 001，CON：16.3 ±19.8%，p = .015），组间无显着差异。从 T0 到 T1 没有显着变化，组间肌纤维尺寸也没有显着差异。对于每根纤维的肌核，I 型纤维中 CON 的非统计显着性增加和 ST 的非统计显着性减少在组间趋于不同 (p = .053)。卫星细胞 ST 趋于减少（I 型：-14±±36%，p=±.097，II 型：-9±±55%，p=±.084），CON 没有变化，组间没有差异。与常规护理相比，化疗期间的力量训练可改善肌肉力量，但不会显着影响身体成分、肌纤维大小、卫星细胞数量和肌核。© 2024 美国实验生物学会联合会。

To investigate the effects of heavy-load strength training during (neo-)adjuvant chemotherapy in women with breast cancer on muscle strength, body composition, muscle fiber size, satellite cells, and myonuclei. Women with stage I-III breast cancer were randomly assigned to a strength training group (ST, n = 23) performing supervised heavy-load strength training twice a week during chemotherapy, or a usual care control group (CON, n = 17). Muscle strength and body composition were measured and biopsies from m. vastus lateralis collected before the first cycle of chemotherapy (T0) and after chemotherapy and training (T1). Muscle strength increased significantly more in ST than in CON in chest-press (ST: +10 ± 8%, p < .001, CON: -3 ± 5%, p = .023) and leg-press (ST: +11 ± 8%, p < .001, CON: +3 ± 6%, p = .137). Both groups reduced fat-free mass (ST: -4.9 ± 4.0%, p < .001, CON: -5.2 ± 4.9%, p = .004), and increased fat mass (ST: +15.3 ± 16.5%, p < .001, CON: +16.3 ± 19.8%, p = .015) with no significant differences between groups. No significant changes from T0 to T1 and no significant differences between groups were observed in muscle fiber size. For myonuclei per fiber a non-statistically significant increase in CON and a non-statistically significant decrease in ST in type I fibers tended (p = .053) to be different between groups. Satellite cells tended to decrease in ST (type I: -14 ± 36%, p = .097, type II: -9 ± 55%, p = .084), with no changes in CON and no differences between groups. Strength training during chemotherapy improved muscle strength but did not significantly affect body composition, muscle fiber size, numbers of satellite cells, and myonuclei compared to usual care.© 2024 Federation of American Societies for Experimental Biology.