单阴离子金双（二硫醇）复合物最近被证明具有对抗卵巢癌细胞、革兰氏阳性菌、念珠菌菌株和啮齿动物疟原虫伯氏疟原虫的活性。迄今为止，仅对具有被小烷基链取代的噻唑啉主链的单阴离子金(III)双(二硫醇烯)配合物进行了生物医学应用评估。我们现在分析了这些复合物烷基链的长度和疏水性与亲水性对其抗癌和抗疟原虫特性的影响。还研究了这些单阴离子金（III）双（二硫醇烯）配合物的异构体类似物（这次具有噻唑主链），以评估杂环配体的性质对其整体化学和生物性质的影响。在本报告中，我们介绍了四种具有长烷基链和多氧化（PEG）链的新型单阴离子金（III）双（二硫醇烯）配合物的全合成，旨在提高其溶解度和生物性质。我们的结果表明，带有 PEG 链的复合物除了提高溶解度（药物发现和开发的关键参数）之外，还显示出有前景的抗癌和抗疟原虫活性。

Monoanionic gold bis(dithiolene) complexes were recently shown to display activity against ovarian cancer cells, Gram-positive bacteria, Candida strains and the rodent malaria parasite, P. berghei. To date, only monoanionic gold(III) bis(dithiolene) complexes with a thiazoline backbone substituted with small alkyl chains have been evaluated for biomedical applications. We now analyzed the influence of the length and the hydrophobicity vs. hydrophilicity of these complexes' alkyl chain on their anticancer and antiplasmodial properties. Isomer analogues of these monoanionic gold(III) bis(dithiolene) complexes, this time with a thiazole backbone, were also investigated in order to assess the influence of the nature of the heterocyclic ligand on their overall chemical and biological properties. In this report we present the total synthesis of four novel monoanionic gold(III) bis(dithiolene) complexes with a long alkyl chain and a polyoxygenated (PEG) chain aiming to improve their solubility and biological properties. Our results showed that the complexes with a PEG chain showed promising anticancer and antiplasmodial activities beside improved solubility, a key parameter in drug discovery and development.