诱导化疗后局部晚期胰腺癌（LAPC）患者接受手术的情况正在增加。然而，大多数系列并未报告接受手术探查的患者总数；因此，这项单中心研究调查了所有连续接受手术探查的 LAPC 患者的结果。我们进行了一项回顾性、单中心分析，包括所有连续接受手术探查的 LAPC（荷兰胰腺癌组标准）患者（ 2014年1月至2023年6月）诱导治疗后。主要结局是切除率和自诊断时起的总生存期 (OS)。 总体而言，127 名患者接受了 LAPC 手术探查，其中 100 名患者 (78.7%) 接受了切除术，27 名患者 (21.3%) 接受了非治疗性剖腹手术。血管受累（n = 11，8.7%）或隐匿性转移（n = 16，12.6%）。院内/30 天总体死亡率为 0.8%，主要发病率为 31.3%（切除后患者：分别为 1.0% 和 33.3%）。总体 90 天死亡率为 5.5%，其中因疾病进展导致的死亡率为 3.1%。切除与较长的中位 OS 相关（29 个月（95% 置信区间 [CI] 26-43）与 17 个月（95% CI 11-26））； p < 0.001} 与接受非治疗性剖腹手术的患者相比，相应的 5 年 OS 率为 28.4% 和 7.7%。在Cox比例风险回归分析中，只有胰腺体/尾部肿瘤独立预测OS（风险比1.788 [95% CI 1.042-3.068]）。该单中心系列发现选择进行手术探查的LAPC患者的切除率为78.7% ，所有探索的患者的死亡率和发病率均较低，切除后 5 年 OS 率为 28.4%。© 2024。作者。

The use of surgery in patients with locally advanced pancreatic cancer (LAPC) following induction chemotherapy is increasing. However, most series do not report on the total cohort of patients undergoing surgical exploration; therefore, this single-center study investigates outcomes among all consecutive patients with LAPC who underwent surgical exploration.We conducted a retrospective, single-center analysis including all consecutive patients with LAPC (Dutch Pancreatic Cancer Group criteria) who underwent surgical exploration with curative intent (January 2014-June 2023) after induction therapy. Primary outcomes were resection rate and overall survival (OS) from the time of diagnosis.Overall, 127 patients underwent surgical exploration for LAPC, whereby 100 patients (78.7%) underwent resection and 27 patients (21.3%) underwent a non-therapeutic laparotomy due to the extent of vascular involvement (n = 11, 8.7%) or occult metastases (n = 16, 12.6%). The overall in-hospital/30-day mortality rate was 0.8% and major morbidity was 31.3% (in patients after resection: 1.0% and 33.3%, respectively). The overall 90-day mortality rate was 5.5%, which included 3.1% mortality due to disease progression. Resection was associated with longer median OS {29 months (95% confidence interval [CI] 26-43) vs. 17 months (95% CI 11-26); p < 0.001} compared with patients undergoing non-therapeutic laparotomy, with corresponding 5-year OS rates of 28.4% and 7.7%. In Cox proportional hazard regression analysis, only pancreatic body/tail tumors independently predicted OS (hazard ratio 1.788 [95% CI 1.042-3.068]).This single-center series found a resection rate of 78.7% in patients with LAPC selected for surgical exploration, with a low risk of mortality and morbidity in all explored patients and a 5-year OS rate after resection of 28.4%.© 2024. The Author(s).