背景格林-巴利综合征（GBS）是一种罕见的免疫介导的周围神经疾病。在非感染因素中，手术已被确定为该疾病的潜在触发因素。本报告介绍了一名 74 岁男性的病例，他在接受肺腺癌右下肺叶切除术后 15 天后患上 GBS。病例报告 我们介绍了一名前吸烟者因局限性肺腺癌接受单孔视频辅助 (U-VATS) 右下肺叶切除术的病例。手术后十五天，他表现出双侧下肢无力、广泛的感觉异常和姿势不稳定。综合诊断检查，包括临床评估、血清学测试、脑脊液 (CSF) 分析和神经传导研究 (NCS)，证实了诊断。值得注意的是，CSF 分析显示白蛋白细胞学解离，白蛋白 453.2 mg/L、蛋白质 757 mg/L、葡萄糖 67 mg/dl、3 个白细胞 (WBC)/uL 和多形核 (PMN) 33%。 NCS 表现出运动和感觉异常。每天立即静脉注射免疫球蛋白 (IVIG) 2 g/kg，持续 5 天，可在 3 个月内完全康复。结论 该病例强调了及时识别和治疗 GBS 作为术后并发症的重要性。神经学检查、神经影像学和电生理学研究对于准确诊断至关重要。 IVIG 治疗仍然是 GBS 治疗的基石，在该病例中观察到了良好的结果。提高临床医生对手术与 GBS 之间潜在关联的认识对于预防更严重的并发症和确保最佳的患者管理至关重要。进一步的研究对于确定肺部手术后 GBS 的精确发病机制和机制至关重要。

BACKGROUND Guillain-Barre syndrome (GBS) is a rare immune-mediated peripheral nerve disorder. Among non-infectious factors, surgery has been identified as a potential trigger of the disease. This report presents the case of a 74-year-old man who developed GBS 15 days after a right lower lobectomy for lung adenocarcinoma. CASE REPORT We present a case of a patient who was a former smoker who underwent uniportal video-assisted (U-VATS) right lower lobectomy for localized lung adenocarcinoma. Fifteen days after surgery, he exhibited bilateral lower-limb weakness, widespread paresthesia, and postural instability. Comprehensive diagnostic workup, including clinical assessment, serological tests, cerebrospinal fluid (CSF) analysis, and nerve conduction studies (NCS), confirmed the diagnosis. Notably, CSF analysis revealed albumin-cytological dissociation, with albumin 453.2 mg/L, protein 757 mg/L, glucose 67 mg/dl, 3 white blood cells (WBC)/uL, and polymorphonucleates (PMN) 33%. NCS demonstrated motor and sensory abnormalities. Prompt administration of intravenous immunoglobulins (IVIG) 2 g/kg daily for 5 days resulted in complete recovery within 3 months. CONCLUSIONS This case emphasizes the importance of prompt recognition and management of GBS as a postoperative complication. Neurological examination, neuroimaging, and electrophysiological studies are essential for accurate diagnosis. IVIG therapy remains a cornerstone in GBS management, with favorable outcomes observed in this case. Enhanced awareness among clinicians about the potential association between surgery and GBS is vital to prevent more serious complications and ensure optimal patient management. Further research is crucial to determine the precise pathogenesis and mechanisms of GBS following lung surgery.