幽门螺杆菌是一种革兰氏阴性细菌，感染着全球大约一半的人口。它与胃癌、消化性溃疡和慢性胃炎等胃肠道疾病密切相关。此外，大量研究已将这种细菌与各种胃外疾病联系起来，包括血液、心血管和神经系统问题。具体来说，研究表明幽门螺杆菌通过微生物群-肠-脑轴与大脑相互作用，从而增加神经系统疾病的风险。幽门螺杆菌引起的慢性胃炎释放的炎症介质可能通过干扰神经递质的传递或直接作用来破坏血脑屏障的功能。本文探讨了幽门螺杆菌与一系列疾病之间的相关性，例如高同型半胱氨酸血症、精神分裂症、阿尔茨海默病、帕金森病、缺血性中风、多发性硬化症、偏头痛和吉兰-巴利综合征。版权所有 © 2024 Elsevier B.V. 保留所有权利。

Helicobacter pylori, a type of gram-negative bacterium, infects roughly half of the global population. It is strongly associated with gastrointestinal disorders like gastric cancer, peptic ulcers, and chronic gastritis. Moreover, numerous studies have linked this bacterium to various extra-gastric conditions, including hematologic, cardiovascular, and neurological issues. Specifically, research has shown that Helicobacter pylori interacts with the brain through the microbiota-gut-brain axis, thereby increasing the risk of neurological disorders. The inflammatory mediators released by Helicobacter pylori-induced chronic gastritis may disrupt the function of the blood-brain barrier by interfering with the transmission or direct action of neurotransmitters. This article examines the correlation between Helicobacter pylori and a range of conditions, such as hyperhomocysteinemia, schizophrenia, Alzheimer's disease, Parkinson's disease, ischemic stroke, multiple sclerosis, migraine, and Guillain-Barré syndrome.Copyright © 2024 Elsevier B.V. All rights reserved.