细胞分裂周期相关蛋白（CDCA）家族对于调节细胞分裂很重要。高CDCA表达与肿瘤发展显着相关。本综述总结了近几十年来针对CDCA进行的临床和基础研究。系统介绍了CDCA的分子表达和功能、关键机制、细胞周期调控以及在肿瘤发生发展、细胞增殖、耐药、侵袭和转移中的作用。此外，它还介绍了针对CDCA的肿瘤诊断、预后和治疗的最新研究。这些发现对于进一步深入研究CDCA在促进肿瘤发展中的作用至关重要，并为其作为新的抗肿瘤靶点的应用提供理论支持。版权所有©2024。由Elsevier B.V.出版。

The cell division cycle-associated protein (CDCA) family is important in regulating cell division. High CDCA expression is significantly linked to tumor development. This review summarizes clinical and basic studies on CDCAs conducted in recent decades. Furthermore, it systematically introduces the molecular expression and function, key mechanisms, cell cycle regulation, and roles of CDCAs in tumor development, cell proliferation, drug resistance, invasion, and metastasis. Additionally, it presents the latest research on tumor diagnosis, prognosis, and treatment targeting CDCAs. These findings are pivotal for further in-depth studies on the role of CDCAs in promoting tumor development and provide theoretical support for their application as new anti-tumor targets.Copyright © 2024. Published by Elsevier B.V.