越来越多的证据表明，免疫异常参与了精神分裂症的病理生理学。然而，免疫与临床特征之间的关系尚未明确。本研究的目的是测量肿瘤坏死因子 α (TNF-α) 和可溶性 TNF-α 受体 1 (sTNF-α R1) 的血浆水平，并研究它们与首发精神分裂症患者 (FEPS) 躁动的关系。 .使用夹心酶联免疫吸附测定 (ELISA) 在有 (n = 36) 和无躁动 (n = 49) 症状的 FEPS 以及健康对照 (HCs, n = 54）。采用阳性和阴性症状量表（PANSS）评估精神病理，采用PANSS兴奋成分（PANSS-EC）评估躁动症状。有和无躁动症状患者血浆TNF-α水平显着高于对照组在 HC 中。与无躁动的患者相比，有躁动的患者血浆 TNF-α 水平显着升高。三组间sTNF-α R1水平无显着差异。此外，血浆TNF-α水平与FEPS中的PANSS总分、阳性和一般精神病理分项以及PANSS-EC评分呈正相关，但与血浆sTNF-α R1水平没有发现这种关系。这些结果表明TNF-α 可能在精神分裂症躁动症状的发生和发展中发挥重要作用。© 2024。作者。

Increasing evidence suggested that immune abnormalities involved in the pathophysiology of schizophrenia. However, the relationship between immunity and clinical features has not been clarified. The aim of this study was to measure the plasma levels of tumor necrosis factor alpha (TNF-α) and soluble TNF-α receptor 1 (sTNF-α R1) and to investigate their association with agitation in first episode patients with schizophrenia (FEPS).The plasma TNF-α and sTNF-α R1 levels were measured using sandwich enzyme-linked immunosorbent assay (ELISA) in the FEPS with (n = 36) and without agitation (n = 49) symptoms, and healthy controls (HCs, n = 54). The psychopathology was assessed by the Positive and Negative Syndrome Scale (PANSS), and the agitation symptoms were evaluated by the PANSS excitatory component (PANSS-EC).The plasma TNF-α levels in patients with and without agitation symptoms were significantly higher than those in HCs. The patients with agitation had significantly higher plasma TNF-α levels compared to the patients without agitation. There were no significant differences in the sTNF-α R1 levels among the three groups. Furthermore, the plasma TNF-α levels were positively correlated with the PANSS total score, Positive and General psychopathological subscores, and PANSS-EC score in the FEPS, but the relationships were not found for the plasma sTNF-α R1 levels.These results suggested that TNF-α might play an important role in the onset and development of agitation symptoms of schizophrenia.© 2024. The Author(s).