肯尼亚癌症儿童的长春新碱暴露：CHAPATI 可行性研究。
Vincristine exposure in Kenyan children with cancer: CHAPATI feasibility study.
发表日期：2024 Jul 02
作者：
Aniek Uittenboogaard, Mirjam van de Velde, Lisa van de Heijden, Leah Mukuhi, Niels de Vries, Sandra Langat, Gilbert Olbara, Alwin D R Huitema, Terry Vik, Gertjan Kaspers, Festus Njuguna
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS
摘要：
肯尼亚儿童长春新碱诱发的周围神经病 (VIPN) 的发病率较低，可能是由于长春新碱暴露量较低所致。我们研究了肯尼亚儿童的长春新碱暴露情况，并在长春新碱暴露量较低的情况下增加剂量（NCT05844670）。平均长春新碱暴露量较高。使用先前开发的列线图评估个体长春新碱暴露量。对于低暴露且无 VIPN、高胆红素血症或营养不良的参与者，建议增加 20% 的剂量。 15 名参与者中没有人开发过 VIPN。一名参与者发现长春新碱暴露量较低：增加剂量后没有副作用。总之，尽管长春新碱暴露量较高，但参与者并未出现 VIPN。© 2024 作者。儿科血液
The low incidence of vincristine-induced peripheral neuropathy (VIPN) in Kenyan children may result from low vincristine exposure. We studied vincristine exposure in Kenyan children and dose-escalated in case of low vincristine exposure (NCT05844670). Average vincristine exposure was high. Individual vincristine exposure was assessed with a previously developed nomogram. A 20% dose increase was recommended for participants with low exposure and no VIPN, hyperbilirubinemia, or malnutrition. None of the 15 participants developed VIPN. Low vincristine exposure was seen in one participant: a dose increase was implemented without side effects. In conclusion, the participants did not develop VIPN despite having high vincristine exposure.© 2024 The Author(s). Pediatric Blood & Cancer published by Wiley Periodicals LLC.