柑橘类水果中存在的生物活性化合物在肿瘤学领域获得了更广泛的认可。许多研究已经在人类和动物研究中阐明了柚皮素的抗氧化和抗癌潜力。柚皮素 (NGE) 可能抑制癌症进展，从而改善癌症患者的健康。柚皮素的多效抗癌特性包括抑制生长因子和细胞因子的合成、抑制细胞周期以及修饰多种细胞信号传导途径。作为一种草药，柚皮素具有显着的药理特性，例如抗炎、抗氧化、神经保护、保肝和抗癌活性。体外和体内研究数据证明，用纯柚皮素、负载柚皮素的纳米颗粒以及柚皮素与抗癌药物联合治疗后，致癌物会被灭活。这些研究包括结肠癌、肺癌、乳腺癌、白血病和淋巴瘤、胰腺癌、前列腺肿瘤、口腔鳞状细胞癌、肝癌、脑肿瘤、皮肤癌、宫颈癌和卵巢癌、膀胱肿瘤、胃癌和骨肉瘤。这篇叙述性综述涵盖了柚皮素对乳腺癌炎症、细胞凋亡、增殖、血管生成、转移和侵袭相关过程的影响，以及其开发新型安全抗癌药物的潜力。版权所有 © 2024 Elsori、Pandey、Ramniwas 、库马尔、拉坎帕尔、拉布、西迪基、辛格、赛义德和汗。

The bioactive compounds present in citrus fruits are gaining broader acceptance in oncology. Numerous studies have deciphered naringenin's antioxidant and anticancer potential in human and animal studies. Naringenin (NGE) potentially suppresses cancer progression, thereby improving the health of cancer patients. The pleiotropic anticancer properties of naringenin include inhibition of the synthesis of growth factors and cytokines, inhibition of the cell cycle, and modification of several cellular signaling pathways. As an herbal remedy, naringenin has significant pharmacological properties, such as anti-inflammatory, antioxidant, neuroprotective, hepatoprotective, and anti-cancer activities. The inactivation of carcinogens following treatment with pure naringenin, naringenin-loaded nanoparticles, and naringenin combined with anti-cancer agents was demonstrated by data in vitro and in vivo studies. These studies included colon cancer, lung neoplasms, breast cancer, leukemia and lymphoma, pancreatic cancer, prostate tumors, oral squamous cell carcinoma, liver cancer, brain tumors, skin cancer, cervical and ovarian cancers, bladder neoplasms, gastric cancer, and osteosarcoma. The effects of naringenin on processes related to inflammation, apoptosis, proliferation, angiogenesis, metastasis, and invasion in breast cancer are covered in this narrative review, along with its potential to develop novel and secure anticancer medications.Copyright © 2024 Elsori, Pandey, Ramniwas, Kumar, Lakhanpal, Rab, Siddiqui, Singh, Saeed and Khan.