对于颅内生殖细胞肿瘤（iGCT）个体来说，延迟诊断对肿瘤相关预后的影响似乎很小。然而，其对神经内分泌功能的影响仍不清楚。我们的目的是评估延迟诊断对鞍上 GCT 个体神经内分泌功能的影响。我们对 459 名鞍上 GCT 个体进行了回顾性队列研究，并根据疾病持续时间将其分为两组：延迟诊断（> 6 个月）和非延迟诊断。 - 延迟诊断（≤ 6 个月）。比较两组的内分泌症状、神经内分泌功能障碍及其分级（根据严重程度分为0-3级）以及神经内分泌功能障碍的恢复情况。延迟诊断的患者闭经、生长缓慢、疲劳、多尿/多饮的发生率较高。神经内分泌功能障碍，包括中枢性肾上腺功能不全（CAI）、中枢性甲状腺功能减退症（CHT）、精氨酸加压素缺乏（AVP-D）、生长激素缺乏、性腺功能减退和高催乳素血症，在诊断时、治疗结束时延迟诊断组更为明显，以及最后的后续行动。此外，延迟诊断的个体在诊断时表现出较高级别的神经内分泌功能障碍（OR=3.005，95% CI 1.929-4.845，p<0.001），肿瘤治疗结束时（OR=4.802，95% CI 2.878-8.004，p<0.001） ），以及调整混杂因素后的最后一次随访（OR=2.335，95% CI 1.307-4.170，p=0.005）。最后，在治疗后延迟诊断的组中，恢复较少，特别是 CAI、CHT 和 AVP-D。在患有鞍上 GCT 的个体中，延迟诊断与神经内分泌功能障碍增加、更严重和恢复较差相关，强调早期诊断和治疗对于减少神经内分泌功能障碍的重要性。版权所有 © 2024 Tong、Xu、Chen、Mo、Liang 和 Zhu。

The impact of delayed diagnosis on tumor-related prognosis appears to be minimal in individuals with intracranial germ cell tumors (iGCTs). However, its effect on neuroendocrine functions remains unclear. We aimed to assess the effects of delayed diagnosis on neuroendocrine function in individuals with suprasellar GCTs.We conducted a retrospective cohort study of 459 individuals with suprasellar GCTs and categorized them into two groups based on disease duration: delayed diagnosis (> 6 months) and non-delayed diagnosis (≤ 6 months). We compared endocrinological symptoms, neuroendocrine dysfunction and its grading (categorized into 0-3 grades based on severity), and recovery from neuroendocrine dysfunction in both groups.Patients with delayed diagnosis exhibited higher incidences of amenorrhea, slow growth, fatigue, and polyuria/polydipsia. Neuroendocrine dysfunction, including central adrenal insufficiency (CAI), central hypothyroidism (CHT), arginine vasopressin deficiency (AVP-D), growth hormone deficiency, hypogonadism, and hyperprolactinemia, was more pronounced in the delayed diagnosis group at diagnosis, the end of treatment, and the last follow-up. Furthermore, individuals with delayed diagnosis showed higher grades of neuroendocrine dysfunction at diagnosis (OR=3.005, 95% CI 1.929-4.845, p<0.001), end of oncologic treatment (OR=4.802, 95% CI 2.878-8.004, p<0.001), and last follow-up(OR=2.335, 95% CI 1.307-4.170, p=0.005) after adjusting for confounders. Finally, less recovery, particularly in CAI, CHT, and AVP-D, was seen among the group with delayed diagnosis after treatment.Among individuals with suprasellar GCTs, delayed diagnosis is associated with increased, more severe, and less recovered neuroendocrine dysfunction, emphasizing the importance of early diagnosis and treatment to reduce neuroendocrine dysfunction.Copyright © 2024 Tong, Xu, Chen, Mo, Liang and Zhong.