诺卡氏菌通常被认为是影响免疫功能低下个体的罕见机会性病原体，在涉及免疫功能正常宿主感染的各种病例报告中也有记录。通过吸入或接种到受损皮肤来传播。随后，它可以通过血行传播导致播散性感染，影响几乎所有与中枢神经系统有特殊亲和力的器官。播散至肾上腺的情况极为罕见，仅报告了少数病例。在本报告中，我们提出了一个罕见的播散性诺卡氏菌病例，最初类似于健康个体中的转移性肾上腺恶性肿瘤。该患者表现出非特异性症状，多组血培养呈阴性，临床结果提示潜在的肾上腺恶性肿瘤，并且缺乏可识别的诺卡氏菌危险因素，这给诊断带来了重大挑战。此外，我们回顾了有关肾上腺诺卡氏菌病的现有文献。该病例是文献中第三例报告的诺卡氏菌肾上腺脓肿病例。版权所有 © 2024，Daniel 等人。

Nocardia, typically recognized as an uncommon opportunistic pathogen affecting immunocompromised individuals, has also been documented in various case reports involving infections in immunocompetent hosts. Transmission occurs through inhalation or inoculation into compromised skin. Subsequently, it can lead to disseminated infection via hematogenous spread, affecting nearly any organ with a particular affinity for the central nervous system. Dissemination to the adrenal glands is extremely rare, with only a few cases reported. In this report, we present a rare case of disseminated Nocardia cyriacigeorgica, initially resembling a metastatic adrenal gland malignancy in an otherwise healthy individual. The patient presented with non-specific symptoms, had multiple sets of negative blood cultures, clinical findings suggestive of an underlying adrenal gland malignancy, and lacked identifiable risk factors for Nocardia, creating a significant diagnostic challenge. Additionally, we review the existing literature on nocardiosis involving the adrenal glands. This case marks the third reported instance of a Nocardia cyriacigeorgica adrenal gland abscess in the literature.Copyright © 2024, Daniel et al.