消化系统癌症占癌症病例的很大一部分，但其负担并不均匀。随着全球癌症观察站 (GLOBOCAN) 2022 最近更新了其对癌症负担的估计，我们旨在调查全球和中国六种主要消化系统癌症的负担，以及癌症特定发病率和死亡率的地理和时间变化。我们从 GLOBOCAN 数据库中提取了 2022 年食管癌、胃癌、结直肠癌、肝癌、胰腺癌和胆囊癌的原发性癌症数据。按性别、国家、地区和人类发展指数 (HDI) 计算并分层了年龄标准化发病率和死亡率。 ）。我们利用联合国2022年修订版《世界人口展望》获取了1988年至2012年中国各年龄段的人口数据，并利用连接点模型和平均年度百分比变化（AAPC）分析了中国癌症发病趋势。 2022 年，全球消化系统癌症发病率估计达到 4,905,882 例，癌症相关死亡人数估计为 3,324,774 例。就发病率和死亡率而言，结直肠癌最为普遍。胃肠道癌症的负担与国家 HDI 之间存在显着相关性。 1988年至2012年，中国食管癌、胃癌和肝癌发病率呈下降趋势，而结直肠癌和胰腺癌发病率持续上升。到 2050 年，就发病率和死亡率而言，结直肠癌和肝癌预计仍将分别是中国的主要癌症类型。消化系统癌症仍然是全球和中国的重大公共卫生挑战。尽管一些癌症的预防和控制取得了进展，但消化系统癌症的负担仍然存在。必须加强三级预防策略的实施，以降低消化系统癌症的发病率和死亡率，减轻其对公众健康的影响。版权所有 © 2024 中华医学会，由 Wolters Kluwer, Inc. 制作，CC-BY-NC- ND 许可证。

Digestive system cancers constitute a significant number of cancer cases, but their burden is not uniform. As Global Cancer Observatory (GLOBOCAN) 2022 has recently updated its estimates of cancer burden, we aimed to investigate the burden of six major digestive system cancers both worldwide and in China, along with geographical and temporal variations in cancer-specific incidence and mortality.We extracted data on primary cancers of the esophagus, stomach, colorectum, liver, pancreas, and gallbladder from the GLOBOCAN database for 2022. Age-standardized incidence and mortality rates were calculated and stratified by sex, country, region, and human development index (HDI). We used the 2022 revision of the World Population Prospects (United Nations) to obtain demographic data for various age groups in China from 1988 to 2012 and used the joinpoint model and the average annual percentage change (AAPC) to analyze cancer incidence trends in China.In 2022, the estimated global incidence of digestive system cancers reached 4,905,882, with an estimated 3,324,774 cancer-related deaths. Colorectal cancer was most prevalent in terms of incidence and mortality. There was a significant correlation between the burden of gastrointestinal cancers and country HDI. From 1988 to 2012, the incidence of esophageal, gastric, and liver cancers declined in China, whereas colorectal and pancreatic cancer incidences continued to increase. By 2050, colorectal and liver cancers are projected to remain the leading cancer types in China in terms of incidence and mortality, respectively.Digestive system cancers remain a significant public health challenge globally and in China. Although progress has been made in the prevention and control of some cancers, the burden of digestive system cancers persists. The implementation of tertiary prevention strategies must be intensified to reduce the incidence and mortality of digestive system cancers, mitigating their impact on public health.Copyright © 2024 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.