在当今社会，肺癌的死亡率很高，威胁着人类的健康。肺癌领域使用的传统诊断技术通常需要使用大量仪器，存在假阳性倾向，并且不适合广泛的早期筛查目的。治疗肺癌的传统方法主要包括手术、化疗和放疗。然而，这些广谱治疗方法存在靶向不精确和副作用大等缺点，限制了其广泛使用。金属有机框架（MOF）由于其可调节的电子特性和结构以及潜在的应用，在肺癌的诊断和治疗中引起了极大的关注。这些多孔纳米材料是通过金属中心和有机配体的复杂组装形成的，从而形成高度通用的框架。与传统的诊断和治疗方式相比，MOFs可以提高肺癌诊断中肺癌生物标志物检测的敏感性。在治疗方面，它们可以显着减少副作用，提高治疗效果。因此，这一观点概述了 MOF 作为肺癌生物标志物的有效生物传感器领域所取得的进展。它还深入研究了使用 MOF 作为药物输送载体的最新研究。此外，它还探索了MOF在各种治疗方法中的应用，包括化学动力学疗法、光动力学疗法、光热疗法和免疫疗法。此外，本文全面分析了MOF作为生物传感器在肺癌诊断领域的潜在应用，并结合不同的治疗方法以提高治疗效果。它还对现有障碍进行了简要概述，旨在为肺癌诊断和治疗的未来进步铺平道路。

Nowadays in our society, lung cancer is exhibiting a high mortality rate and threat to human health. Conventional diagnostic techniques used in the field of lung cancer often necessitate the use of extensive instrumentation, exhibit a tendency for false positives, and are not suitable for widespread early screening purposes. Conventional approaches to treat lung cancer primarily involve surgery, chemotherapy, and radiotherapy. However, these broad-spectrum treatments suffer from drawbacks such as imprecise targeting and significant side effects, which restrict their widespread use. Metal-organic frameworks (MOFs) have attracted significant attention in the diagnosis and treatment of lung cancer owing to their tunable electronic properties and structures and potential applications. These porous nanomaterials are formed through the intricate assembly of metal centers and organic ligands, resulting in highly versatile frameworks. Compared to traditional diagnostic and therapeutic modalities, MOFs can improve the sensitivity of lung cancer biomarker detection in the diagnosis of lung cancer. In terms of treatment, they can significantly reduce side effects and improve therapeutic efficacy. Hence, this perspective provides an overview concerning the advancements made in the field of MOFs as potent biosensors for lung cancer biomarkers. It also delves into the latest research dealing with the use of MOFs as carriers for drug delivery. Additionally, it explores the applications of MOFs in various therapeutic approaches, including chemodynamic therapy, photodynamic therapy, photothermal therapy, and immunotherapy. Furthermore, this review comprehensively analyses potential applications of MOFs as biosensors in the field of lung cancer diagnosis and combines different therapeutic approaches aiming for enhanced therapeutic efficacy. It also presents a concise overview of the existing obstacles, aiming to pave the way for future advancements in lung cancer diagnosis and treatment.