调节雄激素受体 (AR) 生物活性的主要机制涉及越来越多的翻译后修饰 (PTM)。在这篇综述中，我们总结了目前关于影响这一主要转录因子的 PTM 的结构和功能影响的知识。接下来，我们讨论这些不同 PTM 之间的串扰以及 AR 蛋白中修饰残基簇的存在。最后，我们讨论了这些共价修饰对脊髓和延髓肌萎缩症（肯尼迪病）和前列腺癌等疾病病因学的影响，以及药物干预的前景。© 2024 作者。由波特兰出版社有限公司代表生化学会出版。

A major mechanism to modulate the biological activities of the androgen receptor (AR) involves a growing number of post-translational modifications (PTMs). In this review we summarise the current knowledge on the structural and functional impact of PTMs that affect this major transcription factor. Next, we discuss the cross-talk between these different PTMs and the presence of clusters of modified residues in the AR protein. Finally, we discuss the implications of these covalent modifications for the aetiology of diseases such as spinal and bulbar muscular atrophy (Kennedy's disease) and prostate cancer, and the perspectives for pharmacological intervention.© 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.