乳腺癌是最常见的恶性肿瘤，也是全世界女性死亡的主要原因。 Atramacronoid A (AM-A) 是从白术 (Atractylodes macrocephala Koidz) 的根茎中分离得到的一种独特的天然倍半萜内酯。我们的研究表明，AM-A 会引发一种特定形式的细胞死亡，类似于 PANoptosis 样细胞死亡。进一步分析表明，AM-A 诱导的 PANoptosis 样细胞死亡与 CASP-3/PARP-GSDMD-MLKL 途径相关，该途径由线粒体功能障碍介导。这些结果表明 AM-A 作为先导化合物的潜力，并为从天然产物中开发乳腺癌治疗剂提供了见解。

Breast cancer is the most common malignant tumor and a major cause of mortality among women worldwide. Atramacronoid A (AM-A) is a unique natural sesquiterpene lactone isolated from the rhizome of Atractylodes macrocephala Koidz (known as Baizhu in Chinese). Our study demonstrated that AM-A triggers a specific form of cell death resembling PANoptosis-like cell death. Further analysis indicated that AM-A-induced PANoptosis-like cell death is associated with the CASP-3/PARP-GSDMD-MLKL pathways, which are mediated by mitochondrial dysfunction. These results suggest the potential of AM-A as a lead compound and offer insights for the development of therapeutic agents for breast cancer from natural products.