大蒜素（AL）是大蒜衍生的有机硫化物之一，具有多种药理作用。研究表明，AL对肝癌、胃癌、乳腺癌等多种癌症有显着的抑制作用。但其在人鼻咽癌中的作用尚无相关报道。铁死亡是一种铁依赖性非凋亡调节细胞死亡形式。越来越多的证据表明，诱导铁死亡可以抑制各种癌细胞的增殖、迁移、侵袭和存活，从而在癌症中发挥抑癌作用。在本研究中，我们证实AL可以抑制人鼻咽癌细胞的增殖、迁移、侵袭和存活。我们的研究结果表明，AL 可以通过降低 GSH 和 GPX4 的水平并促进有毒 LPO 和 ROS 的诱导来诱导铁死亡轴。人鼻咽癌细胞中 AL 介导的细胞毒性依赖于铁死亡。因此，AL具有良好的抗癌特性，有望成为治疗鼻咽癌的潜在药物。

Allicin (AL) is one of garlic-derived organosulfides and has a variety of pharmacological effects. Studies have reported that AL has notable inhibitory effects on liver cancer, gastric cancer, breast cancer, and other cancers. However, there are no relevant reports about its role in human nasopharyngeal carcinoma. Ferroptosis is an iron-dependent form of non-apoptotic regulated cell death. Increasing evidence indicates that induction of ferroptosis can inhibit the proliferation, migration, invasion, and survival of various cancer cells, which act as a tumor suppressor in cancer. In this study, we confirmed that AL can inhibit cell proliferation, migration, invasion, and survival in human nasopharyngeal carcinoma cells. Our finding shows that AL can induce the ferroptosis axis by decreasing the level of GSH and GPX4 and promoting the induction of toxic LPO and ROS. AL-mediated cytotoxicity in human nasopharyngeal carcinoma cells is dependent on ferroptosis. Therefore, AL has good anti-cancer properties and is expected to be a potential drug for the treatment of nasopharyngeal carcinoma.