由脂质过氧化的积累和对铁的依赖引发的铁死亡对于维持细胞平衡至关重要。与铁死亡相关的研究激增，因为与其他形式的受控细胞死亡相比，其在机制和外观方面都有独特的特征。科学家认为，针对铁死亡的努力可以为创新的精准癌症治疗铺平道路，解决癌症复发和耐药等挑战。这篇综述系统地概述了铁死亡背后的分子机制、诱导铁死亡的物质以及不同的癌症如何对铁死亡诱导剂做出反应。此外，该研究还进一步探讨了肿瘤生物学中铁死亡的分子基础。它提供了一个概念框架，说明其与肿瘤免疫微环境的相互作用，指导治疗选择，预测疗效，探索联合疗法，并确定新的治疗靶点以克服癌症对标准治疗的耐药性。最后，它强调了铁死亡作为癌症治疗潜在策略的未来研究和临床转化中的关键问题和障碍。

Ferroptosis, triggered by the buildup of lipid peroxidation and reliance on iron, is crucial in maintaining cellular balance. Research related to ferroptosis has surged due to its distinct characteristics compared to other forms of controlled cell death, both in terms of mechanisms and appearance. Scientists believe that directing efforts towards targeting ferroptosis could pave the way for innovative precision cancer treatments, addressing challenges such as cancer recurrence and resistance. This review systematically outlines the molecular mechanisms behind ferroptosis, the substances that induce ferroptosis, and how different cancers respond to ferroptotic inducers. Also, the study further looks into the molecular basis of ferroptosis in tumor biology. It provides a conceptual framework illustrating its interaction with the tumor immune microenvironment, guiding treatment choices, predicting efficacy, exploring combination therapies, and identifying new therapeutic targets to overcome cancer resistance to standard treatments. Finally, it highlights key issues and obstacles in future research and clinical translation of ferroptosis as a potential strategy in cancer therapy.