近年来，基于先天免疫激活的抗肿瘤策略受到研究人员的青睐。特别是，针对抗吞噬信号传导阻断以增强吞噬作用的策略已被广泛报道。例如，添加钙网蛋白等前吞噬细胞信号可以使该策略显着更有效。在这项研究中，报道了一种将光动力疗法 (PDT) 与 CD47 阻断相结合的抗肿瘤策略。这种方法通过PDT介导的肿瘤免疫原性细胞死亡促进树突状细胞的成熟和肿瘤抗原的呈递，以及增强肿瘤区域的细胞毒性T淋巴细胞浸润和吞噬细胞的吞噬活性。此外，CD47蛋白的下调和阻断可以进一步促进吞噬细胞的吞噬活性，增强先天免疫系统，最终提高抗肿瘤功效并抑制肿瘤转移。

The antitumor strategies based on innate immunity activation have become favored by researchers in recent years. In particular, strategies targeting antiphagocytic signaling blockade to enhance phagocytosis have been widely reported. For example, the addition of prophagocytic signals such as calreticulin could make the strategy significantly more effective. In this study, an antitumor strategy that combines photodynamic therapy (PDT) with CD47 blockade has been reported. This approach promotes the maturation of dendritic cells and the presentation of tumor antigens by PDT-mediated tumor immunogenic cell death, as well as the enhancement of cytotoxic T lymphocyte infiltration in tumor areas and the phagocytic activity of phagocytes. Furthermore, the downregulation and blockage of CD47 protein could further promote phagocytic activity, strengthen the innate immune system, and ultimately elevate the antitumor efficacy and inhibit tumor metastasis.