研究人员探讨了 BA.5 感染后灭活疫苗接种所产生的特异性体液免疫反应，以及 BA.5 感染恢复的鼻咽癌 (BA.5-RNPC) 患者中 XBB 变体再次感染的预测因子。 血清 SARS-CoV-使用酶联免疫吸附测定法评估2种特异性抗体水平。进行单变量和多变量二元 Logistic 回归分析，以确定与特异性体液免疫程度和 XBB 变体再次感染易感性相关的因素。我们的数据表明，BA.5-RNPC 之间的 SARS-CoV-2 特异性抗体水平相当患者和 BA.5 感染恢复的非癌性 (BA.5-RNC) 个体。具体而言，抗祖先-S1-IgG、抗祖先核衣壳蛋白(NP)-IgG、抗-BA.5-受体结合域(RBD)-IgG和抗-XBB.1.1.6-RBD的血清水平与先前未感染的患者相比，BA.5-RNPC 患者的 -IgG 较高。与未接种疫苗的 BA.5-RNPC 患者相比，接受灭活疫苗接种的个体表现出显着更高水平的抗祖先-S1-IgG 和抗-XBB.1.16-RBD-IgG。多变量逻辑回归分析显示，灭活疫苗接种是所有测试的 SARS-CoV-2 特异性抗体反应的最重要预测因素。后续分析表明，低球蛋白水平是 BA.5-RNPC 患者 XBB 再次感染的独立危险因素。接种疫苗的 BA.5-RNPC 患者中 SARS-CoV-2 特异性抗体有所改善。然而，基线免疫状态生物标志物 IgG 是 BA.5-RNPC 患者 XBB 变异再感染风险的指标。版权所有 © 2024。由 Elsevier Inc. 出版。

The specific humoral immune response resulting from inactivated vaccination following by BA.5 infection, and predictors of XBB variants re-infection in BA.5 infection-recovered nasopharyngeal carcinoma (BA.5-RNPC) patients, were explored.Serum SARS-CoV-2 specific antibody levels were assessed using enzyme-linked-immunosorbent-assay. Univariate and multivariate binary logistic regression analyses were conducted to identify factors associated with the magnitude of specific humoral immunity and susceptibility to re-infection by XBB variants.Our data demonstrates that SARS-CoV-2 specific antibody levels were comparable between BA.5-RNPC patients and BA.5 infection-recovered-non-cancerous (BA.5-RNC) individuals. Specifically, serum levels of anti-ancestral-S1-IgG, anti-ancestral-nucleocapsid-protein (NP)-IgG, anti-BA.5-receptor binding domain (RBD)-IgG and anti-XBB.1.1.6-RBD-IgG were higher in BA.5-RNPC patients compared to those without a prior infection. Compared to BA.5-RNPC patients without vaccination, individuals who received inactivated vaccination exhibited significantly higher levels of anti-ancestral-S1-IgG and anti-XBB.1.16-RBD-IgG. Multivariate logistic regression analysis revealed that inactivated vaccination was the most significant predictor of all tested SARS-CoV-2 specific antibodies response. Subsequent analysis indicated that a low globulin level is an independent risk factor for XBB re-infection in BA.5-RNPC patients.The SARS-CoV-2 specific antibodies have been improved in vaccinated BA.5-RNPC patients. However, the baseline immunity status biomarker IgG is an indicators of XBB variant re-infection risk in BA.5-RNPC patients.Copyright © 2024. Published by Elsevier Inc.