一种罕见的神经内分泌皮肤癌，称为默克尔细胞癌 (MCC)，主要影响老年人。本研究的目的是全面回顾免疫抑制药物，特别是 TNF 抑制剂对 MCC 出现的影响。检索了 PubMed、Web of Science、Science Direct 和 Cochrane Library。研究文章在Rayyan卡塔尔计算研究所按标题和摘要进行筛选，然后进行全文评估。共纳入8篇病例报告，涉及9名患者。总人口中，有七名女性，只有两名男性。他们的年龄从31岁到73岁不等。超过一半的人口（5 例）正在接受类风湿性关节炎治疗。所有患者都接受了与 MCC 诱导相关的 TNF 抑制剂治疗。我们发现，医生在开始长期免疫抑制治疗之前向患者解释潜在的癌症风险并对 MCC 和其他副作用进行常规检查至关重要。 TNF 抑制剂（英夫利昔单抗、阿达木单抗、依那西普和戈利木单抗）均与 MCC 的发展相关。女性占病例的大多数，而且大多数是老年人。

A rare neuroendocrine skin cancer called Merkel cell carcinoma (MCC) primarily affects elderly people. The objective of this study is to comprehensively review the impact of immunosuppressive medications, particularly TNF inhibitors, on the emergence of MCC.PubMed, Web of Science, Science Direct, and Cochrane Library were searched. Study articles were screened by title and abstract at Rayyan Qatar Computing Research Institute, then a full-text assessment was implemented.A total of eight case reports with 9 patients were included. Of the total population, seven were women and only two were men. Their age ranged from 31 to 73 years. More than half the population (5 cases) were being treated for rheumatoid arthritis. All received TNF inhibitors that were associated with the induction of MCC.We found that it is essential for physicians to explain potential cancer risks to patients before starting long-term immunosuppressive therapy and to conduct routine checks for MCC and other side effects. TNF inhibitors (infliximab, adalimumab, etanercept, and golimumab) were all associated with MCC development. Women constituted the majority of cases and most were elderly.