从临床和病理角度来看，皮肤肉芽肿反应多种多样。大多数潜在的病理生理学方面仍然难以捉摸。间质性肉芽肿性皮炎和栅栏状中性粒细胞性和肉芽肿性皮炎被认为是对全身性疾病（例如感染性、炎症性或肿瘤性疾病）的反应。最近，创造了一个总体术语“反应性肉芽肿性皮炎”来统一这两个实体。我们在此报告了两例反应性肉芽肿性皮炎，表现为众所周知但不常见的“绳索征”，并提供了临床病理学相关性。这两名患者包括一名 53 岁女性，其躯干两侧靠近腋窝处有增大的红斑，并可触及绳索征（绳索征）；另一名患者为 51 岁女性，有类风湿性关节炎病史，躯干两侧可触及绳索征。行李箱的左侧。两例病例的病理结果均符合反应性肉芽肿性皮炎。总之，绳索征代表了反应性肉芽肿性皮炎的一种罕见但决定性的诊断线索。

Cutaneous granulomatous reactions are diverse, both from the clinical and the pathological perspective. Most underlying pathophysiological aspects remain elusive. Interstitial granulomatous dermatitis and palisaded neutrophilic and granulomatous dermatitis have been claimed to be reactions to systemic disorders, such as infectious, inflammatory, or neoplastic conditions. Recently, the overarching term "reactive granulomatous dermatitis" has been coined to unify both entities. We herein report two cases of reactive granulomatous dermatitis presenting with the widely known, albeit infrequent "rope sign" and provide clinicopathological correlation. The two patients included a 53-year-old woman with enlarging erythematous plaques and underlying palpable cords on both sides of trunk near axillae (rope sign), and a 51-year-old woman with personal history of rheumatoid arthritis and a palpable cord on the left aspect of the trunk. Pathological findings were compatible with reactive granulomatous dermatitis in both cases. In conclusion, the rope sign represents a strikingly infrequent but decisive diagnostic clue of reactive granulomatous dermatitis.