囊泡装载有多种货物，包括膜蛋白、分泌蛋白、信号分子和各种酶等。毫不奇怪，囊泡运输对于正常的细胞生命活动（包括生长、分裂、运动和细胞通讯）至关重要。可溶性 N-乙基马来酰亚胺敏感因子附着蛋白受体 (SNARE) 介导囊泡与其目标区室的膜融合，这对于货物输送至关重要。最近的研究表明，多个 SNARE 家族成员在人类癌症中异常表达，并积极促进恶性增殖、侵袭、转移、免疫逃避和治疗抵抗。在这里，首先绘制了 SNARE 蛋白在真核细胞中的定位和功能。然后我们总结了 SNARE 在癌症中的表达和调控，并描述了它们对癌症进展的贡献和机制，最后我们提出工程化肉毒毒素作为针对 SNARE 进行癌症治疗的策略。版权所有 © 2024。由 Elsevier B.V 出版。

Vesicles are loaded with a variety of cargoes, including membrane proteins, secreted proteins, signaling molecules, and various enzymes, etc. Not surprisingly, vesicle transport is essential for proper cellular life activities including growth, division, movement and cellular communication. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) mediate membrane fusion of vesicles with their target compartments that is fundamental for cargo delivery. Recent studies have shown that multiple SNARE family members are aberrantly expressed in human cancers and actively contribute to malignant proliferation, invasion, metastasis, immune evasion and treatment resistance. Here, the localization and function of SNARE proteins in eukaryotic cells are firstly mapped. Then we summarize the expression and regulation of SNAREs in cancer, and describe their contribution to cancer progression and mechanisms, and finally we propose engineering botulinum toxin as a strategy to target SNAREs for cancer treatment.Copyright © 2024. Published by Elsevier B.V.