循环游离线粒体 DNA (ccf-mtDNA) 已成为一种有前景的生物标志物，对疾病诊断具有潜在影响。线粒体 DNA 的变化，例如缺失、突变或拷贝数变化，与线粒体疾病、心脏病、癌症和与年龄相关的非传染性疾病有关。以前的方法，例如基于聚合酶链反应的方法、下一代测序和基于成像的技术，在识别罕见 mtDNA 变异或突变方面显示出更高的准确性，但它们也有局限性。本文解释了使用基于平面光波导的检测设备的基本原理和优点，它代表了传感领域的先进方法。版权所有 © 2024 Elsevier Ltd。保留所有权利。

Circulating cell-free mitochondrial DNA (ccf-mtDNA) has emerged as a promising biomarker, with potential implications for disease diagnosis. Changes in mtDNA, such as deletions, mutations or variations in the number of copies, have been associated with mitochondrial disorders, heart diseases, cancer and age-related non-communicable diseases. Previous methods, such as polymerase chain reaction-based approaches, next-generation sequencing and imaging-based techniques, have shown improved accuracy in identifying rare mtDNA variants or mutations, but they have limitations. This article explains the basic principles and benefits of using planar optical waveguide-based detection devices, which represent an advanced approach in the field of sensing.Copyright © 2024 Elsevier Ltd. All rights reserved.