化学动力学疗法（CDT）是一种通过过氧化氢（H2O2）催化生成剧毒羟自由基（·OH）来消灭肿瘤细胞的方法，具有肿瘤特异性和副作用最小的独特优势。然而，目前CDT的治疗效果因·OH的生产效率低而受到阻碍。为了解决这一局限性，本研究引入了一种水溶性壳聚糖涂层的W掺杂MoOx（WMoOx/CS），专为光热疗法（PTT）与CDT的联合应用而设计。采用水热法一步合成了W掺杂MoOx（WMoOx），并通过水溶性壳聚糖（羧化壳聚糖，CS）对其表面进行修饰以增强其生物相容性。 WMoOx具有高达52.66%的近红外光热转换效率，可有效地将近红外辐射转化为热量。此外，WMoOx中的Mo4/Mo5和W5离子催化H2O2产生用于CDT的·OH，WMoOx中的Mo5/Mo6和W6离子降低细胞内谷胱甘肽水平并阻止谷胱甘肽对·OH的清除。至关重要的是，WMoOx/CS 和近红外光照射的结合在体外和体内模型中都表现出了有希望的协同抗肿瘤作用，凸显了其联合应用 PTT 和 CDT 的潜力。版权所有 © 2024。由 Elsevier B.V. 出版。

Chemodynamic therapy (CDT), an approach that eradicates tumor cells through the catalysis of hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (·OH), possesses distinct advantages in tumor specificity and minimal side effects. However, CDT's therapeutic efficacy is currently hampered by the low production efficiency of ·OH. To address this limitation, this study introduces a water-soluble chitosan-coated W-doped MoOx (WMoOx/CS) designed for the combined application of photothermal therapy (PTT) combined with CDT. The W-doped MoOx (WMoOx) was synthesized in one step by the hydrothermal method, and its surface was modified by water-soluble chitosan (carboxylated chitosan, CS) to enhance its biocompatibility. WMoOx boasts a high near-infrared photothermal conversion efficiency of 52.66 %, efficiently transducing near-infrared radiation into heat. Moreover, the Mo4+/Mo5+ and W5+ ions in WMoOx catalyze H2O2 to produce ·OH for CDT, and the Mo5+/Mo6+ and W6+ ions in WMoOx reduce intracellular glutathione levels and prevent the scavenging of ·OH by glutathione. Crucially, the combination of WMoOx/CS and near-infrared light irradiation demonstrates promising synergistic antitumor effects in both in vitro and in vivo models, highlighting its potential for the combined application of PTT and CDT.Copyright © 2024. Published by Elsevier B.V.