有关心脏骤停 (SCA) 的癌症患者治疗的数据很少。我们的目的是根据癌症病史评估 SCA 的特征和结果。基于人群的前瞻性登记，包括 2011 年至 2019 年间巴黎及其郊区每例院外 SCA 成人，特别关注癌症患者在 4069 名住院的 SCA 患者中，207 名 (5.1%) 目前或既往有癌症病史。癌症患者年龄较大（69.2 岁 vs 59.3 岁，p<0.001），女性患者更常见（37.2% vs 28.0%，p=0.006），且潜在心血管疾病更常见（41.1% vs 32.5%，p=0.01）。不可电击节律时 SCA 的发生率更高（62.6% vs 43.1%，p<0.001），在目击者在场和进行心肺复苏 (CPR) 方面没有显着差异。癌症患者中心脏原因较少见（主要为急性冠状动脉综合征，分别为 25.5% vs 46.8%，p<0.001），而呼吸系统原因则较多（肺栓塞和低氧血症分别为 34.2% vs 10.8%，p<0.001）。尽管如此，癌症患者与其他患者相比，SCA 后的院内生存率没有发现差异（分别为 26.2% 和 29.8%，p=0.27）。公共场所、目击者心肺复苏和可电击节律是癌症组 SCA 后院内生存的独立预测因素。 二十分之一的 SCA 发生在有癌症病史的患者中，但与无癌症患者相比，心脏原因较少。尽管如此，即使对于患有已知癌症的患者，院内结果仍然相似。因此，癌症史不应影响 SCA 中复苏的启动。© 作者（或其雇主）2024。不得商业重复使用。请参阅权利和权限。英国医学杂志出版。

Data on the management of patients with cancer presenting with sudden cardiac arrest (SCA) are scarce. We aimed to assess the characteristics and outcomes of SCA according to cancer history.Prospective, population-based registry including every out-of-hospital SCA in adults in Paris and its suburbs, between 2011 and 2019, with a specific focus on patients with cancer.Out of 4069 patients who had SCA admitted alive in hospital, 207 (5.1%) had current or past medical history of cancer. Patients with cancer were older (69.2 vs 59.3 years old, p<0.001), more often women (37.2% vs 28.0%, p=0.006) with more frequent underlying cardiovascular disease (41.1% vs 32.5%, p=0.01). SCA happened more often with a non-shockable rhythm (62.6% vs 43.1%, p<0.001) with no significant difference regarding witness presence and cardiopulmonary resuscitation (CPR) performed. Cardiac causes were less frequent among patients with cancer (mostly acute coronary syndromes, 25.5% vs 46.8%, p<0.001) and had more respiratory causes (pulmonary embolism and hypoxaemia in 34.2% vs 10.8%, p<0.001). Still, no difference regarding in-hospital survival was found after SCA in patients with cancer versus other patients (26.2% vs 29.8%, respectively, p=0.27). Public location, CPR by witness and shockable rhythm were independent predictors of in-hospital survival after SCA in the cancer group.One in 20 SCA occurs in patients with a history of cancer, yet with fewer cardiac causes than in patients who are cancer-free. Still, in-hospital outcomes remain similar even in patients with known cancer. Cancer history should therefore not compromise the initiation of resuscitation in the context of SCA.© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.