该研究旨在评估这些生物标志物对自闭症谱系障碍 (ASD) 儿童样本的影响，以帮助早期诊断和干预。 共有 71 名自闭症患者和 65 名正常对照者参加了这项研究。他们的年龄从 5 岁到 11 岁不等（平均值 ± 标准差 7.47 ± 3.81）。对所有患者和对照组进行了儿童自闭症评定量表（CARS）评估。对氧化应激、单核细胞趋化蛋白-1、B 细胞淋巴瘤 2、S-腺苷同型半胱氨酸 (SAH) 和 apelin 进行评估。氧化应激（氧化低密度脂蛋白和丙二醛）增加，而抗氧化对氧磷酶 (PON) 减少。单核细胞趋化蛋白-1、B 细胞淋巴瘤 2 和 S-腺苷同型半胱氨酸 (SAH) 均升高，而 apelin 下调。值得注意的是，许多可能导致 ASD 的因素包括遗传因素。为了打开新治疗策略的大门，仍然有必要准确了解氧化应激、趋化因子、细胞凋亡和甲基化能力如何影响 ASD 患者的新陈代谢。© 2024 Walter de Gruyter GmbH，柏林/波士顿。

The study aimed to assess the effect of these biomarkers on a sample of children with autism spectrum disorder (ASD) to help in early diagnosis and intervention.A total of 71 autistic patients and 65 normal controls were enrolled in this study. Their ages ranged from 5 to 11 years (mean ± SD 7.47 ± 3.81). Childhood Autism Rating Scale (CARS) was assessed for all patients and controls. Assessment of oxidative stress, monocyte chemoattractant protein-1, B-cell lymphoma 2, S-adenosylhomocysteine (SAH), and apelin was performed.Oxidative stress (oxidized low-density lipoprotein and malonaldehyde) increased while antioxidant paraoxonase (PON) decreased. Monocyte chemoattractant protein-1, B-cell lymphoma 2, and S-adenosylhomocysteine (SAH) were all elevated whereas, apelin was downregulated.It is important to note that many factors that may contribute to ASD including genetic factors. To open the door for novel treatment strategies, it is still necessary to precisely understand how oxidative stress, chemokines, apoptosis, and methylation capability affect the metabolism of people with ASD.© 2024 Walter de Gruyter GmbH, Berlin/Boston.