尽管肝细胞癌（HCC）具有恶性程度高、发病率高、生存率低等特点，但其发病机制尚未完全阐明。铁死亡是一种非凋亡形式的受控细胞死亡，与其他类型的细胞死亡相比，具有独特的形态、生化和遗传特征。调节铁死亡的分子网络内的失调行为已被确定为 HCC 进展的重要因素。长非编码 RNA (lncRNA) 已成为多种细胞过程的有影响力的贡献者，通过多种机制途径调节基因功能和表达。越来越多的证据表明，失调的 lncRNA 通过影响 HCC 中的铁死亡而参与调节细胞增殖、生长、侵袭和代谢等恶性事件。因此，阐明铁死亡的内在作用以及lncRNA对HCC铁死亡的调节功能可能会促进该疾病新型治疗干预措施的开发。本综述简要概述了铁死亡和铁死亡相关的 lncRNA 在 HCC 进展和治疗中的作用，旨在推动 HCC 患者有前景的治疗靶点和生物标志物的开发。© 2024。作者。

Despite being characterized by high malignancy, high morbidity, and low survival rates, the underlying mechanism of hepatocellular carcinoma (HCC) has not been fully elucidated. Ferroptosis, a non-apoptotic form of regulated cell death, possesses distinct morphological, biochemical, and genetic characteristics compared to other types of cell death. Dysregulated actions within the molecular network that regulates ferroptosis have been identified as significant contributors to the progression of HCC. Long non-coding RNAs (lncRNAs) have emerged as influential contributors to diverse cellular processes, regulating gene function and expression through multiple mechanistic pathways. An increasing body of evidence indicates that deregulated lncRNAs are implicated in regulating malignant events such as cell proliferation, growth, invasion, and metabolism by influencing ferroptosis in HCC. Therefore, elucidating the inherent role of ferroptosis and the modulatory functions of lncRNAs on ferroptosis in HCC might promote the development of novel therapeutic interventions for this disease. This review provides a succinct overview of the roles of ferroptosis and ferroptosis-related lncRNAs in HCC progression and treatment, aiming to drive the development of promising therapeutic targets and biomarkers for HCC patients.© 2024. The Author(s).