成纤维细胞生长因子 (FGF) 是一个多功能的肽生长因子家族，参与多种生物功能，包括细胞生长和分化、胚胎发育、血管生成和代谢。异常的 FGF/FGF 受体 (FGFR) 信号传导与癌症、代谢性疾病和炎症性疾病等多种疾病的发病机制有关。值得注意的是，巨噬细胞极化涉及不同的功能表型，在组织修复、稳态维持和免疫反应中发挥着至关重要的作用。最近的证据表明，FGF/FGFR 信号传导密切参与巨噬细胞的极化，表明它们可能是与功能失调的巨噬细胞相关的疾病的治疗操作的潜在靶点。在本文中，我们概述了 FGF 的结构、功能和下游调控途径，以及 FGF 信号传导与巨噬细胞极化之间的串扰。此外，我们总结了利用 FGF 信号传导调节巨噬细胞极化的潜在应用。版权所有 © 2024 Shen、Li 和 Zhu。

Fibroblast growth factors (FGFs) are a versatile family of peptide growth factors that are involved in various biological functions, including cell growth and differentiation, embryonic development, angiogenesis, and metabolism. Abnormal FGF/FGF receptor (FGFR) signaling has been implicated in the pathogenesis of multiple diseases such as cancer, metabolic diseases, and inflammatory diseases. It is worth noting that macrophage polarization, which involves distinct functional phenotypes, plays a crucial role in tissue repair, homeostasis maintenance, and immune responses. Recent evidence suggests that FGF/FGFR signaling closely participates in the polarization of macrophages, indicating that they could be potential targets for therapeutic manipulation of diseases associated with dysfunctional macrophages. In this article, we provide an overview of the structure, function, and downstream regulatory pathways of FGFs, as well as crosstalk between FGF signaling and macrophage polarization. Additionally, we summarize the potential application of harnessing FGF signaling to modulate macrophage polarization.Copyright © 2024 Shen, Li and Zhao.