肠道菌群与结直肠癌（CRC）发生、发展和治疗之间的相关性或因果关系的研究越来越受到重视。与此同时，结直肠癌的发病率和死亡率因个体和地区的不同而存在差异，肠道微生物群也存在差异。为了更好地了解CRC患者肠道菌群的特征以及不同地区之间的差异，我们首先使用16S比较了中国中部地区（湖北省）的25名CRC患者和26名健康对照者的肠道菌群rRNA高通量测序技术。结果显示，结直肠癌患者体内棒状杆菌、肠球菌、乳酸菌和埃希氏菌志贺菌显着富集。此外，我们还利用PICRUSt的功能预测分析比较了CRC组和健康对照组之间功能通路的潜在差异。然后，我们将其与来自中国不同地区（包括华中、华东和东北）的五项队列研究进行了分析和比较。我们发现地理因素可能影响结直肠癌患者肠道微生物群的组成。肠道微生物群的组成是影响结直肠癌筛查、早期检测和预测结直肠癌治疗结果的重要信息。这强调了在中国不同地区开展结直肠癌相关肠道微生物群研究的重要性。版权所有 © 2024 Shi、Shen、Huang、Zhan、Chen、Zhou、Lv、Xiong、Jiang、Chen 和 Liu。

The research on the correlation or causality between gut microbiota and the occurrence, development, and treatment of colorectal cancer (CRC) is receiving increasing emphasis. At the same time, the incidence and mortality of colorectal cancer vary among individuals and regions, as does the gut microbiota. In order to gain a better understanding of the characteristics of the gut microbiota in CRC patients and the differences between different regions, we initially compared the gut microbiota of 25 CRC patients and 26 healthy controls in the central region of China (Hubei Province) using 16S rRNA high-throughput sequencing technology. The results showed that Corynebacterium, Enterococcus, Lactobacillus, and Escherichia-Shigella were significantly enriched in CRC patients. In addition, we also compared the potential differences in functional pathways between the CRC group and the healthy control group using PICRUSt's functional prediction analysis. We then analyzed and compared it with five cohort studies from various regions of China, including Central, East, and Northeast China. We found that geographical factors may affect the composition of intestinal microbiota in CRC patients. The composition of intestinal microbiota is crucial information that influences colorectal cancer screening, early detection, and the prediction of CRC treatment outcomes. This emphasizes the importance of conducting research on CRC-related gut microbiota in various regions of China.Copyright © 2024 Shi, Shen, Huang, Zhan, Chen, Zhou, Lv, Xiong, Jiang, Chen and Liu.