肺癌被全球公认为是恶性肿瘤相关发病率和死亡率的主要原因，其高患病率和致死率的特点引起了医学界的广泛关注。线粒体自噬是一个关键的细胞过程，在调节新陈代谢和确保细胞内的质量控制方面发挥着至关重要的作用。它与肺癌的相关性引起了研究人员和科学家的极大关注。线粒体自噬在肺癌中的作用包括其发生、进展、转移扩散和治疗。线粒体自噬的调控环境很复杂，涉及许多信号蛋白和通路，这些信号蛋白和通路可能在肿瘤环境中表现出异常改变或突变。在治疗领域，线粒体自噬的调节被认为是决定癌症化疗、放疗、其他治疗方案和耐药性的关键。当代研究旨在在治疗策略中利用线粒体自噬调节剂（包括抑制剂和激活剂），重点是实现特异性，以尽量减少对健康细胞群的附带损害。此外，与线粒体自噬相关的分子成分和途径作为潜在的生物标志物，为提高肺癌的诊断准确性、预后评估和治疗反应预测提供了有希望的途径。未来的努力还将涉及研究线粒体自噬对肿瘤微环境中免疫细胞的组成和功能的影响，旨在增强我们对线粒体自噬如何调节肺癌免疫反应的理解。本文旨在全面综述线粒体自噬在肿瘤发生、发育和转移中的作用以及线粒体自噬对肺癌治疗影响的最新进展。我们还讨论了线粒体自噬在肺癌领域的未来研究方向。版权所有 © 2024 张，于，唐和陈。

Lung cancer, recognized globally as a leading cause of malignancy-associated morbidity and mortality, is marked by its high prevalence and lethality, garnering extensive attention within the medical community. Mitophagy is a critical cellular process that plays a crucial role in regulating metabolism and ensuring quality control within cells. Its relevance to lung cancer has garnered significant attention among researchers and scientists. Mitophagy's involvement in lung cancer encompasses its initiation, progression, metastatic dissemination and treatment. The regulatory landscape of mitophagy is complex, involving numerous signaling proteins and pathways that may exhibit aberrant alterations or mutations within the tumor environment. In the field of treatment, the regulation of mitophagy is considered key to determining cancer chemotherapy, radiation therapy, other treatment options, and drug resistance. Contemporary investigations are directed towards harnessing mitophagy modulators, both inhibitors and activators, in therapeutic strategies, with an emphasis on achieving specificity to minimize collateral damage to healthy cellular populations. Furthermore, molecular constituents and pathways affiliated with mitophagy, serving as potential biomarkers, offer promising avenues for enhancing diagnostic accuracy, prognostic assessment, and prediction of therapeutic responses in lung cancer. Future endeavors will also involve investigating the impact of mitophagy on the composition and function of immune cells within the tumor microenvironment, aiming to enhance our understanding of how mitophagy modulates the immune response to lung cancer. This review aims to comprehensively overview recent advancements about the role of mitophagy in the tumor genesis, progenesis and metastasis, and the impact of mitophagy on the treatment of lung cancer. We also discussed the future research direction of mitophagy in the field of lung cancer.Copyright © 2024 Zhang, Yu, Tang and Chen.