PANoptosis是促炎性程序性细胞死亡的一种复杂形式，包括细胞凋亡、焦亡和坏死性凋亡，是近年来出现的一个新兴概念，在癌症、传染病和神经系统疾病中得到广泛报道。心血管疾病（CVD）是一个重要的全球健康问题，对个人生命构成严重威胁。越来越多的研究表明炎症在CVD中具有关键作用，这为PANoptosis促进CVD进展提供了重要的理论依据。迄今为止，只有零星的关于 CVD 中的 PANoptosis 的研究被报道，其在 CVD 领域的作用尚未得到充分探讨。阐明各种应激刺激下心肌细胞死亡的各种模式、具体的分子机制以及各种死亡模式之间的联系，对于深入了解CVD的病理生理学具有重要的临床意义。本文综述了细胞凋亡、细胞焦亡、坏死性凋亡和全凋亡的分子机制及其在心血管疾病领域的应用前景。

PANoptosis, a complex form of proinflammatory programmed cell death, including apoptosis, pyroptosis and necroptosis, has been an emerging concept in recent years that has been widely reported in cancer, infectious diseases and neurological disorders. Cardiovascular diseases (CVDs) are an important global health problem, posing a serious threat to individuals' lives. An increasing body of research shows that inflammation has a pivotal role in CVDs, which provides an important theoretical basis for PANoptosis to promote the progression of CVDs. To date, only sporadic studies on PANoptosis in CVDs have been reported and its role in the field of CVDs has not been fully explored. Elucidating the various modes of cardiomyocyte death, the specific molecular mechanisms and the links among the various modes of death under various stressful stimuli is of notable clinical significance for a deeper understanding of the pathophysiology of CVDs. The present review summarizes the molecular mechanisms of apoptosis, pyroptosis, necroptosis and PANoptosis and their prospects in the field of CVDs.