糖尿病与轻度认知障碍 (MCI) 的风险增加有关，这种疾病的特征是轻微的认知能力下降，可能先于痴呆症的发展。连接糖尿病和 MCI 的潜在机制涉及代谢失调、炎症和神经变性之间复杂的相互作用。糖尿病和 MCI 的一个关键机制是炎症通路的激活。正如在糖尿病中观察到的，慢性低度炎症可导致促炎细胞因子的产生，例如肿瘤坏死因子-α (TNF-α)、白细胞介素 6 (IL-6)、白细胞介素 1 β (IL- 1β）和干扰素γ（IFNγ），它们都会加剧神经炎症并导致认知能力下降。 ADAM17 是一种参与调节炎症的关键酶，它是一种解整合素和金属蛋白酶，它可以将 TNF-α 从其膜结合前体中裂解并释放出来，并使其被激活。这些过程反过来又激活其他炎症相关途径，例如 AKT、NF-κB、NLP3、MAPK 和 JAK-STAT 途径。最近的研究为 ADAM17 在糖尿病和神经退行性疾病中的作用提供了新的见解。 ADAM17 在糖尿病和阿尔茨海默病中表达上调，表明存在共同的机制，并暗示炎症可能是导致更广泛病理形式的一个因素，并指出炎症与 MCI 的出现之间可能存在联系。本综述概述了 ADAM17 在糖尿病相关轻度认知障碍疾病中的不同作用。它确定了 ADAM17 和相关途径可能影响轻度认知障碍出现的机制联系。版权所有 © Bentham Science Publishers；如有任何疑问，请发送电子邮件至 epub@benthamscience.net。

Diabetes has been linked to an increased risk of mild cognitive impairment (MCI), a condition characterized by a subtle cognitive decline that may precede the development of dementia. The underlying mechanisms connecting diabetes and MCI involve complex interactions between metabolic dysregulation, inflammation, and neurodegeneration. A critical mechanism implicated in diabetes and MCI is the activation of inflammatory pathways. Chronic low-grade inflammation, as observed in diabetes, can lead to the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1 beta (IL-1β), and interferon-gamma (IFNγ), each of which can exacerbate neuroinflammation and contribute to cognitive decline. A crucial enzyme involved in regulating inflammation is ADAM17, a disintegrin, and metalloproteinase, which can cleave and release TNF-α from its membrane-bound precursor and cause it to become activated. These processes, in turn, activate additional inflammation-related pathways, such as AKT, NF-κB, NLP3, MAPK, and JAK-STAT pathways. Recent research has provided novel insights into the role of ADAM17 in diabetes and neurodegenerative diseases. ADAM17 is upregulated in both diabetes and Alzheimer's disease, suggesting a shared mechanism and implicating inflammation as a possible contributor to much broader forms of pathology and pointing to a possible link between inflammation and the emergence of MCI. This review provides an overview of the different roles of ADAM17 in diabetes-associated mild cognitive impairment diseases. It identifies mechanistic connections through which ADAM17 and associated pathways may influence the emergence of mild cognitive impairment.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.